THE CHARACTERISTICS OF THE OPIOID-RELATED ANALGESIA INDUCED BY THE STRESS OF SWIMMING IN THE MOUSE
THE CHARACTERISTICS OF THE OPIOID-RELATED ANALGESIA INDUCED BY THE STRESS OF SWIMMING IN THE MOUSE
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DOI：
10.1016/0304-3940(82)90110-0
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发表时间：
1982-01-01
影响因子：
2.5
通讯作者：
CARMODY, J
中科院分区：
文献类型：
--
作者：
COOPER, K;CARMODY, J
热板试验显示，在小鼠中，游泳的压力会引起镇痛。对于.apprx。游泳结束后5分钟，镇痛程度保持恒定；此后它会减少，并在 25-30 分钟后检测不到。短至 15 秒的游泳后，镇痛作用就很明显，随着游泳时间的延长（长达 7.5 分钟），镇痛的程度会增加。在体温（38°C）的水中游泳后镇痛效果明显。将 H2O 温度降低至 21°C。 C 轻微增加镇痛作用；进一步减少会大大增加这种镇痛的程度[这可能与内源性阿片类药物有关]。
In mice, the stress of swimming induces analgesia, as revealed by the hot-plate test. For .apprx. 5 min after the end of swimming, the degree of analgesia remains constant; it decreases thereafter and is undetectable after 25-30 min. The analgesia is apparent after a swim as short as 15 s and with longer swims (up to 7.5 min) the magnitude of analgesia increases. Analgesia is apparent after swimming in H2O at body temperature (38.degree. C). Decreasing the H2O temperature to 21.degree. C increases the analgesia slightly; further decreases greatly increase the magnitude of this analgesia [which is probably related to endogenous opiods].