Elevated C-reactive protein associates with early-stage carotid atherosclerosisis in young subjects with type 1 diabetes
Elevated C-reactive protein associates with early-stage carotid atherosclerosisis in young subjects with type 1 diabetes
复制标题
DOI：
10.2337/diacare.25.8.1432
复制
发表时间：
2002-08-01
期刊：
影响因子：
16.2
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Hayaishi-Okano, R;Yamasaki, Y;Hori, M
研究设计与方法：对55例1型糖尿病患者(男性22例，女性33例，年龄22.1+/-3.6岁，糖尿病病程14.2+/-5.7岁)和75例年龄匹配的健康非糖尿病患者(男性28例，女性47例)的颈动脉平均和最大内中膜厚度(IMT)进行B型超声检查。结果：I型糖尿病患者超敏C反应蛋白水平显著高于非糖尿病患者(中位数0.35，0.05~1.47 mg/L vs.0.14，0.05~1.44 mg/L；P=0.001)，平均IMT和最大IMT显著高于非糖尿病患者(平均IMT0.76±0.09vs.0.72±0.04 mm，P=0.003)；最大IMT0.84+/-0.11vs.0.77+/-0.06 mm，P<；0.0001)。Hs-CRP水平与I型糖尿病患者的平均IMT和最大IMT及非糖尿病患者的最大IMT显著相关。对糖尿病组和非糖尿病组的多元回归分析显示，hs-C反应蛋白水平与平均IMT和最大IMT水平独立相关(分别为P=0.002和P=0.023)，并与舒张压、性别和糖尿病病程相关。结论：我们的数据显示年轻的1型糖尿病患者hs-C反应蛋白水平升高，可能与早期晚期颈动脉粥样硬化相关。
OBJECTIVE - To evaluate whether low-grade inflammation contributes to early-stage advanced carotid atherosclerosis in young subjects with type I diabetes.RESEARCH DESIGN AND METHODS - The mean and maximum (max) intima-media thicknesses (IMT) of the carotid artery were assessed using ultrasound B-mode imaging in 55 patients with type 1 diabetes (22 men and 33 women, aged 22.1 +/- 3.6 years (+/- SD), duration of diabetes 14.2 +/- 5.7 years) and 75 age-matched healthy nondiabetic subjects (28 men and 47 women). High-sensitive C-reactive protein (hs-CRP) levels were measured with a latex-enhanced immunonephelometer.RESULTS - The patients with type I diabetes had significantly higher hs-CRP levels (median 0.35, range 0.05-1.47 mg/l vs. median 0.14, range 0.05-1.44 mg/l; P = 0.001) as well as significantly higher mean IMT and max IMT than the nondiabetic subjects (mean IMT 0.76 +/- 0.09 vs. 0.72 +/- 0.04 mm, P = 0.003; max IMT 0.84 +/- 0.11 vs. 0.77 +/- 0.06 mm, P < 0.0001). Hs-CRP levels were significantly correlated with the mean and max IMT of patients with type I diabetes and with the max IMT of nondiabetic patients. Multivariate regression analyses for both diabetic and nondiabetic subjects as a single group showed that hs-CRP levels are independently correlated with the mean IMT and max IMT levels (P = 0.002 and P = 0.023, respectively) as well as with diastolic blood pressure, sex, and duration of diabetes.CONCLUSIONS - Our data indicate that hs-CRP levels are elevated in young patients with type 1 diabetes, possibly corresponding with early-stage advanced carotid atherosclerosis.