Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis
Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis
复制标题
DOI：
10.1159/000371759
复制
发表时间：
2015-01-01
影响因子：
2.1
通讯作者：
Liang, Yiheng
中科院分区：
文献类型：
--
作者：
Fan, Shangrong;Liu, Xiaopingliu;Liang, Yiheng
咪康唑是一种合成咪唑类抗真菌剂，对白色念珠菌和非白色念珠菌具有广谱活性。评价硝酸咪康唑阴道栓与口服氟康唑治疗重度外阴阴道念珠菌病的疗效和安全性。研究方法：在这项前瞻性、随机病例对照研究中，对2009年1月1日至2010年12月31日在北京大学深圳医院妇科门诊连续接受SVVC治疗的577例患者进行了研究。SVVC患者分别用硝酸咪康唑阴道栓1，200 mg或氟康唑150 mg治疗2次。在第二剂治疗后随访7-14天和30-35天。结果如下：随访7-14天，咪康唑组真菌学治愈率为75.9%（220/290），氟康唑组为84.0%（241/287），两组比较差异有显著性（P < 0.05）。第2次随访时，两组真菌学治愈率分别为64.8%（188/290）和69.7%（200/287）（P > 0.05）。结论：该研究表明，在治疗SVVC患者时，两剂硝酸咪康唑阴道栓剂1,200 mg与两剂口服氟康唑150 mg方案同样有效。(C)2015 S. Karger AG，巴塞尔
Aims: Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). Methods: In this prospective, randomized case control study, 577 cases of consecutive patients with SVVC were studied at the Gynecological Clinic of Peking University Shenzhen Hospital from January 1, 2009 through December 31, 2010. Patients with SVVC were treated with two doses of miconazole nitrate vaginal suppository 1,200 mg or two doses of fluconazole 150 mg. The patients were followed up for 7-14 and 30-35 days following the second dose of therapy. Results: The mycological cure rates of the patients on days 7-14 of follow-up were 75.9% (220/290) and 84.0% (241/287) in the miconazole and fluconazole groups, respectively (p < 0.05). The mycological cure rates of the patients at the second follow-up were 64.8% (188/290) and 69.7% (200/287), respectively, in the two groups (p > 0.05). Conclusion: The study demonstrated that two doses of miconazole nitrate vaginal suppository 1,200 mg were as effective as two doses of an oral fluconazole 150 mg regimen in the treatment of patients with SVVC. (C) 2015 S. Karger AG, Basel