Trophoblastic vasculogenic mimicry in gestational choriocarcinoma
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma
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DOI：
10.1038/modpathol.2010.231
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发表时间：
2011-05-01
期刊：
影响因子：
7.5
通讯作者：
Shih, Ie-Ming
中科院分区：
文献类型：
--
作者：
Shih, Ie-Ming
血管生成是实体瘤的特征性特征，其依赖于新形成的血管系统来防止缺氧并维持不受控制的肿瘤细胞增殖。本研究对10例妊娠绒毛膜癌的血供系统进行了组织病理学和免疫组化研究。在所有检查的情况下，形态学分析表明，在绒毛膜癌的中心血管周围的肿瘤滋养层细胞，而不是内皮细胞。同样，绒毛膜癌中缺乏CD 31和CD 34阳性内皮细胞。在绒毛膜癌的外周，肿瘤细胞侵入子宫间质来源的血管，滋养层细胞取代内皮细胞，形成内皮衬里的血管和滋养层衬里的假血管通道之间的闭塞。Masson三色染色显示绒毛膜癌内有少量结缔组织。相反，CD 31和CD 34阳性血管存在于其他类型的妊娠滋养细胞肿瘤，包括8个胎盘部位滋养细胞肿瘤和12个上皮样滋养细胞肿瘤。这些发现提供了有力的证据表明，绒毛膜癌是少数几种利用肿瘤细胞血管生成拟态支持肿瘤发展的人类肿瘤类型之一。Modern Pathology（2011）24，646-652; doi：10.1038/modpathol.2010.231; 2011年1月7日在线发表
Angiogenesis is a characteristic feature of solid tumors, which depend on the newly formed vasculature to prevent hypoxia and to sustain uncontrolled tumor cell proliferation. In this study, we investigated the blood supply system in 10 gestational choriocarcinomas on the basis of histopathological and immunohistochemical features. In all examined cases, morphological analysis demonstrated that blood channels within the center of choriocarcinomas were surrounded by neoplastic trophoblastic cells rather than by endothelial cells. Similarly, there was a lack of CD31 and CD34-positive endothelial cells within choriocarcinomas. In the periphery of choriocarcinomas, tumor cells invaded uterine stroma-derived blood vessels where trophoblastic cells replaced endothelial cells, forming anastomoses between endothelium-lined blood vessels and trophoblastlined pseudovascular channels. Masson's trichrome staining revealed minimal amounts of connective tissue within choriocarcinomas. In contrast, CD31 and CD34-positive blood vessels were present in other types of gestational trophoblastic neoplasms including 8 placental site trophoblastic tumors and 12 epithelioid trophoblastic tumors. These findings provide cogent evidence that choriocarcinoma represents one of a few human tumor types that utilizes vasculogenic mimicry by tumor cell in supporting tumor development. Modern Pathology (2011) 24, 646-652; doi:10.1038/modpathol.2010.231; published online 7 January 2011