Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran.
Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran.
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在喂食含有牛肉脂肪或玉米油（含或不含麦麸）的饮食的大鼠中，二甲基肼诱发结肠肿瘤。
DOI：
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发表时间：
1977
影响因子：
7.1
通讯作者：
L. Wideman
中科院分区：
文献类型：
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作者：
R. Wilson;D. Hutcheson;L. Wideman
SpragueDawley品系雄性大鼠饲喂含有20%牛肉脂肪或玉米油的半合成日粮，加和不加20%小麦麸皮。其中一半的动物接受了每周四次的剂量，另一半接受了每周八次的二甲基肼，30毫克/公斤，通过胃插管。不喂麸皮的大鼠患上所有类型的结肠肿瘤的比例明显高于喂饲麸皮的老鼠。同样，不喂麸皮的大鼠患结肠息肉样肿瘤的百分比较高，但喂饲麸皮的大鼠患结肠恶性肿瘤的百分比没有显著差异。在喂食玉米油的大鼠和喂食牛肉脂肪的大鼠之间，无论是在结肠癌的发病率还是种类上，都没有发现明显的差异。与喂食牛肉脂肪的老鼠相比，喂食玉米油的老鼠更早发生导致死亡的结肠恶性肿瘤。服用八种剂量二甲肼的大鼠患结肠肿瘤的比例和每只荷瘤大鼠的肿瘤数量显着增加，或与服用四种剂量二甲肼的大鼠相比。
Male rats of the Sprague-Dawley strain were fed semisynthetic diets containing either 20% beef fat or corn oil with and without 20% wheat bran. Half of the animals received four weekly doses and the other half received eight weekly doses of dimethylhydrazine, 30 mg/kg, by intragastric intubation. The percentage of rats with tumors of the colon of all types was significantly higher in animals fed no bran than in those fed bran. Likewise, the percentage of rats with polypoid neoplasms of the colon was higher in rats fed no bran, but there was no significant difference in the percentage of rats with malignant tumors of the colon with respect to the feeding of bran. No significant differences were found between rats fed corn oil and those fed beef fat with respect to either the incidence or the kinds of colon tumors. Malignant tumors of the colon, causing death, occurred earlier in rats fed corn oil as compared to those fed beef fat. The percentage of rats with tumors of the colon and the numbers of tumors per tumor-bearing rat were significantly increased in rats given eight doses of dimethylhydrazine or compared to those given four.