CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
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DOI：
10.1186/1476-8518-8-1
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发表时间：
2010-02-04
期刊：
影响因子：
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通讯作者：
Heath, Andrew W
中科院分区：
文献类型：
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作者：
Bhagawati-Prasad, Vijay Ns;De Leenheer, Evy;Heath, Andrew W
主动接种疫苗可以有效地作为暴露后预防，但相对于病原体的潜伏期，诱导的免疫应答的快速性是至关重要的。我们在这里表明，与抗原结合的CD40 mAb比目前使用的免疫佐剂明矾和单磷酰脂质A诱导更快的特异性抗体应答。
Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.