Dynamic variation of bioactive compounds and aflatoxins in contaminated Radix Astragali during extraction process
Dynamic variation of bioactive compounds and aflatoxins in contaminated Radix Astragali during extraction process
复制标题
受污染黄芪提取过程中生物活性成分及黄曲霉毒素的动态变化
DOI：
10.1002/jsfa.7257
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发表时间：
2016-03-30
影响因子：
4.1
通讯作者：
Yang, Meihua
中科院分区：
文献类型：
--
作者：
Hu, Yichen;Kong, Weijun;Yang, Meihua
BACKGROUND: Although increasing attention has been paid to the health threat caused by mycotoxins in commodities such as food or medicines, mycotoxin transfer processes from crude material to products have raised little concern so far. Radix Astragali is a commonly used edible and medicinal herbal plant that is susceptible to contamination with aflatoxins from Aspergillus flavus. There have been no studies on mycotoxin transfer into pharmaceutical preparations or derivative products.RESULTS: To facilitate the aflatoxin reduction and bioactivity retention, the dynamic variations of aflatoxins as well as herbal compounds, namely calycosin-7-glucoside, astragaloside and formononetin, in Radix Astragali contaminated by A. flavus during water decoction and ethanol refluxing treatments were evaluated simultaneously by an ultra-fast liquid chromatography-triple quadrupole linear ion trap mass spectrometry method. After the extraction processes, although the amount of alfatoxins was reduced remarkably, aflatoxin residuals in preparation still exceed recommended limits, manifesting the great need to establish a limit for aflatoxins in herbal extractions or derivative products. Meanwhile, due to the hydrolysis of glucoside, water decoction period should be no longer than 4 h.CONCLUSIONS: This investigation would benefit from the determination of the dynamic variation of aflatoxins in infected herbs in preparation treatments, in order to further develop aflatoxin limits in herbal preparations. (C) 2015 Society of Chemical Industry
