Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children
Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children
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DOI：
10.1186/1465-9921-7-67
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发表时间：
2006-04-20
影响因子：
5.8
通讯作者：
Nordvall, L
中科院分区：
文献类型：
--
作者：
Alving, K;Janson, C;Nordvall, L
背景：呼出气一氧化氮（NO）测定已被证明是一个有价值的工具，在哮喘患者的管理。到目前为止，大多数测量都是用固定的、基于荧光的NO分析仪进行的，这不适合初级卫生保健环境。手持式NO分析仪简化了测量，在专业和初级卫生保健中都有价值。在这项研究中，一种新的电化学手持设备呼出NO测量（NIOX MINO）的性能进行了比较与标准的固定式化学发光单元（NIOX）。方法：共71名受试者（6 - 60岁; 36名男性），健康对照组和过敏性哮喘患者和不包括在内。比较了每个设备中三次批准呼气的平均值（50 ml/s）以及手持设备中第一次批准测量的NO读数（Bland-Altman图）、测量可行性（6次尝试的成功率）和可重复性（受试者内SD）。结果：成人和儿童的两种设备的成功率都很高（>= 84%）。受试者的FENO范围为8 - 147 ppb。当比较三次测量的平均值（n = 61）时，两种设备的呼出NO受试者内差异的中位数为-1.2ppb;因此，通常手持设备的读数略高。Bland-Altman图显示95%一致性限值为-9.8和8.0 ppb。NIOX和NIOX MINO中首次批准测量值之间的受试者内中位差异为-2.0 ppb，一致性限度为-13.2和10.2 ppb。NIOX和NIOX MINO的中位重复性分别为1.1和1.2 ppb，分别。结论：手持式设备（NIOX MINO）和固定系统（NIOX）是在临床上可接受的协议时，三次测量的平均值和第一次批准的测量（NIOX MINO）被使用。手持装置显示出良好的重复性，它可以成功地用于成人和大多数儿童。新的手持设备将能够将呼出的NO测量引入初级卫生保健。
Background: Exhaled nitric oxide ( NO) measurement has been shown to be a valuable tool in the management of patients with asthma. Up to now, most measurements have been done with stationary, chemiluminescence-based NO analysers, which are not suitable for the primary health care setting. A hand-held NO analyser which simplifies the measurement would be of value both in specialized and primary health care. In this study, the performance of a new electrochemical hand-held device for exhaled NO measurements (NIOX MINO) was compared with a standard stationary chemiluminescence unit (NIOX).Methods: A total of 71 subjects ( 6 - 60 years; 36 males), both healthy controls and atopic patients with and without asthma were included. The mean of three approved exhalations ( 50 ml/s) in each device, and the first approved measurement in the hand-held device, were compared with regard to NO readings ( Bland-Altman plots), measurement feasibility ( success rate with 6 attempts) and repeatability (intrasubject SD).Results: Success rate was high (>= 84%) in both devices for both adults and children. The subjects represented a FENO range of 8 - 147 parts per billion (ppb). When comparing the mean of three measurements (n = 61), the median of the intrasubject difference in exhaled NO for the two devices was - 1.2 ppb; thus generally the hand-held device gave slightly higher readings. The Bland-Altman plot shows that the 95% limits of agreement were - 9.8 and 8.0 ppb. The intrasubject median difference between the NIOX and the first approved measurement in the NIOX MINO was - 2.0 ppb, and limits of agreement were - 13.2 and 10.2 ppb. The median repeatability for NIOX and NIOX MINO were 1.1 and 1.2 ppb, respectively.Conclusion: The hand-held device ( NIOX MINO) and the stationary system ( NIOX) are in clinically acceptable agreement both when the mean of three measurements and the first approved measurement ( NIOX MINO) is used. The hand- held device shows good repeatability, and it can be used successfully on adults and most children. The new hand- held device will enable the introduction of exhaled NO measurements into the primary health care.