Thyroid hormone concentrations in depressed and nondepressed adolescents: Group differences and behavioral relations
Thyroid hormone concentrations in depressed and nondepressed adolescents: Group differences and behavioral relations
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DOI：
10.1097/00004583-199603000-00010
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发表时间：
1996-03-01
影响因子：
13.3
通讯作者：
Gold, PW
中科院分区：
文献类型：
--
作者：
Dorn, LD;Burgess, ES;Gold, PW
目的：探讨青少年抑郁症患者甲状腺激素水平及其对情绪和问题行为的影响。方法：选取21名抑郁症青少年和20名正常对照青少年作为研究对象。抽血测量促甲状腺激素（TSH）、游离甲状腺素（FT 4）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）。重性抑郁症（MD），注意力缺陷（AD）和强迫症（OC）症状评分是从儿童诊断访谈表中提取的。还获得了青少年自我报告的总行为问题评分。结果：配对分析显示，TSH、T4或T3没有显著的组或性别差异或组与性别的相互作用。然而，对于FT 4，有显着的组间差异（p= 0.008），显示抑郁症青少年的浓度低于对照组，这表明前者可能是功能性甲状腺功能减退。虽然TSH与所获得的任何心理测量值均无显著相关性，但在抑郁组中，相关性为负（尽管不总是显著的）与FT 4和总行为问题（r=-.40，p=.09），以及MD（r=-.25，p=.288）、OC（r=-.56，p=.011）和AD行为（r=-.57，p=.008）的症状评分。OG和AD的症状评分较高，与FT 4浓度较低有关。结论：抑郁青少年的FT 4浓度较低。这些发现表明青少年抑郁症患者的负性行为与下丘脑-垂体-甲状腺轴功能障碍之间存在关系。
Objective: To examine thyroid hormone concentrations and the influence of these hormones on mood and problem behaviors in adolescents with depression. Method: The sample included 21 depressed adolescents and 20 matched control adolescents. Blood was drawn to measure thyroid-stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), and triiodothyronine (T3). Major depression (MD), attention deficit (AD), and obsessive-compulsive (OC) symptom scores were abstracted from the Diagnostic Interview Schedule for Children. Total behavior problem scores from the Youth Self-Report also were obtained. Results: Paired analysis revealed there were no significant group or gender differences or group by gender interactions for TSH, T4, or T3. For FT4, however, there were significant group differences (p=.008) showing lower concentrations in depressed adolescents than control subjects, suggesting that the former might be functionally hypothyroid. Although there were no significant correlations of TSH with any of the psychological measures obtained, in the depressed group correlations were negative (although not always significant) with FT4 and total behavior problems (r=-.40, p=.09), as well as with symptom scores of MD (r=-.25, p=.288), OC (r=-.56, p=.011), and AD behaviors (r=-.57, p=.008). Higher numbers of symptom scores of OG and AD were related to lower concentrations of FT4. Conclusions: FT4 concentrations were lower in depressed adolescents. These findings suggest a relationship between negative behaviors and dysfunction of the hypothalamic-pituitary-thyroid axis in adolescents with depression.