Iminophosphorane-based preparation of 2,5-disubstituted oxazole derivatives:: Synthesis of the marine alkaloid almazole C
Iminophosphorane-based preparation of 2,5-disubstituted oxazole derivatives:: Synthesis of the marine alkaloid almazole C
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DOI：
10.1055/s-2007-967995
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发表时间：
2007-02-01
期刊：
影响因子：
2
通讯作者：
Molina, Pedro
中科院分区：
文献类型：
--
作者：
Fresneda, Pilar M.;Castaneda, Marta;Molina, Pedro
A four-steps synthesis (32% overall yield) of marine alkaloid almazole C isolated from the red seaweed Haraldiophylum sp. is described. The key step, construction of the central 2,5-disubstituted oxazole ring is based on the aza-Wittig reaction of the iminophosphorane derived from the alpha-azidoacetyl indole and (S)-N-phthaloylphenylalanyl chloride.
