The development and maintenance of resident macrophages.
The development and maintenance of resident macrophages.
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DOI：
10.1038/ni.3341
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发表时间：
2016-01
影响因子：
30.5
通讯作者：
Geissmann F
中科院分区：
文献类型：
--
作者：
Perdiguero EG;Geissmann F
巨噬细胞在体内健康和疾病状态中发挥多种作用，其潜在的分子和细胞机制仍知之甚少。本综述的目的是介绍和讨论巨噬细胞发育生物学的现有知识，因为它是分层髓系系统概念的基础，该系统由主要来源于卵黄囊祖细胞的“驻留”巨噬细胞以及来源于骨髓造血干细胞并更新的“过客”或“暂时性”髓系细胞组成，并为研究巨噬细胞在体内的功能提供一个框架。
The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of macrophages, as it underlies the concept of a layered myeloid system composed of ‘resident’ macrophages that mostly originate from yolk sac progenitors and of ‘passenger’ or ‘transitory’ myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to provide a framework to investigate the functions of macrophages in vivo.