Blockade of specific NOTCH ligands: a new promising approach in cancer therapy.
Blockade of specific NOTCH ligands: a new promising approach in cancer therapy.
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DOI：
10.1158/2159-8290.cd-14-1501
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发表时间：
2015-02
期刊：
影响因子：
28.2
通讯作者：
Iruela-Arispe ML
中科院分区：
文献类型：
--
作者：
Briot A;Iruela-Arispe ML
由Notch受体/配体的不同组合传递的信号传导特异性仍然难以捉摸。在本期《癌症发现》中，通过开发配体特异性Notch抑制剂，Kangsamaksin等人发现了DLL和JAG受体激活下游的独特信号传导结果，并证明了它们在抑制肿瘤血管生成方面的作用。
The signaling specificity conveyed by distinct combination of Notch receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific Notch inhibitors, Kangsamaksin et al. uncovered unique signaling outcomes downstream of DLL- and JAG- receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.