Prevalence of diastolic dysfunction in normotensive, asymptomatic patients with well-controlled type 2 diabetes mellitus
Prevalence of diastolic dysfunction in normotensive, asymptomatic patients with well-controlled type 2 diabetes mellitus
复制标题
DOI：
10.1016/s0002-9149(00)01366-7
复制
发表时间：
2001-02-01
影响因子：
2.8
通讯作者：
Maklady, FA
中科院分区：
文献类型：
--
作者：
Zabalgoitia, M;Ismaeil, MF;Maklady, FA
To evaluate the prevalence of left ventricular (LV) diastolic dysfunction in patients with type 2 diabetes mellitus free of cardiovascular disease, we studied 86 normotensive men and women (mean age 46 +/- 6 years) with Doppler echocardiography, All subjects were asymptomatic for ischemic heart disease or heart failure, The traditional transmitral filling patterns were used to characterize diastolic physiology, The Valsalva maneuver was used to differentiate normal from pseudonormol LV filling pattern, All patients had a normal electrocordiogram at rest and a negative result on exercise echocardiogrophy for inducible wall motion abnormalities, Global LV systolic function was normal (mean LV ejection fraction 58%, range 53% to 76%), Diastolic dysfunction was found in 41 subjects (47%) of which 26 (30%) had impaired relaxation and 15 (17%) had a pseudonormal filling pattern. The mean LV moss index was 101 g/m(2) (range 86 to 122), All patients with a normal-filling physiology had gender-adjusted normal LV mass index (mean 93 +/- 11 g/m(2)), whereas 62% of those with either abnormal relaxation (mean 103 +/- 12 g/m(2), p
