High incidence of type 2 diabetes and increasing conversion rates from impaired fasting glucose and impaired glucose tolerance to diabetes in Mauritius
High incidence of type 2 diabetes and increasing conversion rates from impaired fasting glucose and impaired glucose tolerance to diabetes in Mauritius
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DOI：
10.1111/j.1365-2796.2004.01336.x
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发表时间：
2004-07-01
影响因子：
11.1
通讯作者：
Shaw, J
中科院分区：
文献类型：
--
作者：
Söderberg, S;Zimmet, P;Shaw, J
目标。目的：描述毛里求斯人群中不同阶段葡萄糖耐受不良的发生率，随访超过11年。研究设计、方法和对象。1987年、1992年和1998年在多民族国家毛里求斯进行了以人口为基础的调查，参与者分别为5083、6616和6291人。包括问卷调查、人体测量和2小时75克口服葡萄糖耐量试验。确定了年龄在25至79岁之间具有可分类的葡萄糖耐量数据的三个队列；1987年至1992年为3680人，1992年至1998年为4178人，1987年至1998年为2631人。葡萄糖耐量按WHO 1999标准分级。1992年至1998年2型糖尿病的发病率高于1987年至1992年。在男性中，队列之间的发病率相似（每1000人年24.5和25.4例），而女性的发病率增加（每1000人年23.3和16.4例）。糖尿病发病率在45-54岁年龄组达到高峰，然后趋于平稳或下降。在男性和女性中，糖耐量受损（IGT）和空腹血糖受损（IFG）的发生率均有所下降。在基线时血糖正常的受试者中，发生IGT的女性多于男性，发生IFG的男性多于女性。在1987年被列为IFG的人群中，有38%的人在11年后患上了糖尿病。IGT的相应数字为46%。在这项研究中，我们报告了11年期间葡萄糖耐受不良发生率的变化。研究人员特别观察到男女之间的差异。与男性相比，女性的IGT发病率增加，男性的IFG发病率与女性相比增加，这与这些州患病率中的性别偏见一致，并解释了性别偏见。
Objective. To describe the incidence of different stages of glucose intolerance in a population from Mauritius followed over 11 years.Research design, methods and subjects. Population-based surveys were undertaken in the multi-ethnic nation of Mauritius in 1987, 1992 and 1998 with 5083, 6616 and 6291 participants, respectively. Questionnaires, anthropometric measurements, and a 2-h 75-g oral glucose tolerance test were included. Three cohorts aged between 25 and 79 years with classifiable glucose tolerance data were identified; 3680 between 1987 and 1992, 4178 between 1992 and 1998, and 2631 between 1987 and 1998. Glucose tolerance was classified according to WHO 1999 criteria.Results. The incidence rate of type 2 diabetes was higher between 1992 and 1998 than between 1987 and 1992. In men, the incidence was similar between cohorts (24.5 and 25.4 per 1000 person-years) whereas the incidence increased in women (23.3 and 16.4 per 1000 person-years). The incidence of diabetes peaked in the 45-54 year age group and then plateaud or fell. The incidences of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) decreased in both men and women. Of normoglycaemic subjects at baseline, more women than men developed IGT and more men than women developed IFG. Of those labelled as IFG in 1987, 38% developed diabetes after 11 years. The corresponding figure for IGT was 46%.Conclusions. In this study, we report changes in incidence rates of glucose intolerance over a 11-year period. In particular, differences between men and women were observed. The increased incidence of IGT in women compared with men, and increased incidence of IFG in men compared with women was consistent with, and explains the sex biases seen in the prevalences of these states.