Injection volume and intracameral moxifloxacin dose
Injection volume and intracameral moxifloxacin dose
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DOI：
10.1016/j.jcrs.2019.04.020
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发表时间：
2019-10-01
影响因子：
2.8
通讯作者：
Gardner, Susanne
中科院分区：
文献类型：
--
作者：
Shorstein, Neal H.;Gardner, Susanne
目的：为了测试注射体积和浓度对前房（AC）中阿博沙星给药和停留时间的影响。设置：Kaiser Permanente，核桃溪，加州，美国。设计：实验研究。方法：将莫西沙星0.5%/0.05 mL、阿托沙星0.5%/ 0.10 mL和阿托沙星0.15%/0.50 mL分别抽入5支1.0 mL注射器中，注入去皮重小瓶中，并称重。计算递送的剂量。AC浓度和消除率的药物为两个AC体积建模为each dosing methods.Results：0.05 mL注射体积导致的最大范围（35 μ g）的输送剂量相比，较大的注射体积（
Purpose: To test the effect of injection volume and concentration on dosing and residence time of moxifloxacin in the anterior chamber (AC).Setting: Kaiser Permanente, Walnut Creek, California, USA.Design: Experimental study.Methods: Moxifloxacin 0.5%/0.05 mL, moxifloxacin 0.5%/ 0.10 mL, and moxifloxacin 0.15%/0.50 mL were drawn into 5 1.0 mL syringes each, injected into tared vials, and weighed. The doses delivered were calculated. The AC concentrations and elimination rates of the drug for two AC volumes were modeled for each dosing method.Results: The 0.05 mL injection volume resulted in the greatest range (35 mu g) of delivered dose compared with larger injection volumes (