Dual responsive supramolecular nanogels for intracellular drug delivery

Dual responsive supramolecular nanogels for intracellular drug delivery
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用于细胞内药物递送的双响应超分子纳米凝胶

DOI:
10.1039/c4cc00016a
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发表时间:
2014-01-01
影响因子:
4.9
通讯作者:
Chen, Xuesi
Chen, Xuesi
中科院分区:
化学2区
文献类型:
--
作者:
Chen, Xiaofei;Chen, Li;Chen, Xuesi

文献摘要

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Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-beta-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.