Influence of attention focus on neural activity in the human spinal cord during thermal sensory stimulation
Influence of attention focus on neural activity in the human spinal cord during thermal sensory stimulation
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DOI：
10.1016/j.mri.2010.07.012
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Munoz, Doug P.
中科院分区：
文献类型：
--
作者：
Stroman, Patrick W.;Coe, Brian C.;Munoz, Doug P.
健康人对感觉和疼痛的感知被认为是感觉输入以及脑干和皮质区域根据情感和认知因素进行下行调制的净结果。在这里，注意力对脊髓神经活动的影响，在热感觉刺激的手进行了研究与功能磁共振成像系统地改变参与者的注意力集中在重复的研究。注意力状态包括（1）通过对感觉进行评级来注意刺激，以及（2）通过执行各种心理任务来注意远离刺激，这些心理任务包括观看电影和识别字符，检测随机移动视野中连贯移动的点的方向以及回答具有心理挑战性的问题。跨越颈髓和脑干的功能性MRI结果一致表明，注意力状态对颈髓以及与下行镇痛系统相关的脑干区域的活动有显著影响。这些发现对疼痛的检测和研究具有重要意义，并改善了损伤或疾病影响的表征。(C)2011 Elsevier Inc. All rights reserved.
Perceptions of sensation and pain in healthy people are believed to be the net result of sensory input and descending modulation from brainstem and cortical regions depending on emotional and cognitive factors. Here, the influence of attention on neural activity in the spinal cord during thermal sensory stimulation of the hand was investigated with functional magnetic resonance imaging by systematically varying the participants' attention focus across and within repeated studies. Attention states included (1) attention to the stimulus by rating the sensation and (2) attention away from the stimulus by performing various mental tasks of watching a movie and identifying characters, detecting the direction of coherently moving dots within a randomly moving visual field and answering mentally-challenging questions. Functional MRI results spanning the cervical spinal cord and brainstem consistently demonstrated that the attention state had a significant influence on the activity detected in the cervical spinal cord, as well as in brainstem regions involved with the descending analgesia system. These findings have important implications for the detection and study of pain, and improved characterization of the effects of injury or disease. (C) 2011 Elsevier Inc. All rights reserved.