The effect of water, ascorbic acid, and cranberry derived supplementation on human urine and uropathogen adhesion to silicone rubber.
The effect of water, ascorbic acid, and cranberry derived supplementation on human urine and uropathogen adhesion to silicone rubber.
复制标题
水、抗坏血酸和蔓越莓衍生补充剂对人体尿液和尿路病原体对硅橡胶粘附的影响。
DOI：
10.1139/w99-065
复制
发表时间：
1999
影响因子：
2.8
通讯作者：
G. Reid
中科院分区：
文献类型：
--
作者：
M. Habash;H. C. van der Mei;H. Busscher;G. Reid
在这项研究中，尿液是从饮用水、抗坏血酸或蔓越莓补充剂的志愿者群体中收集的。只有抗坏血酸摄入量一贯产生酸性尿。光光谱数据表明，增加水的消耗产生的尿液蛋白质含量较低。收集的尿液的表面张力测量表明，水和蔓越莓补充剂始终产生的尿液表面张力高于对照组或抗坏血酸摄入后收集的尿液。这些尿液样本还用于研究平行板流动室中尿路病原体对硅橡胶的粘附。补充抗坏血酸或蔓越莓后获得的尿液减少了粘附大肠杆菌和粪肠球菌的初始沉积速率和数量，但没有铜绿假单胞菌，表皮葡萄球菌或白色念珠菌。相反，从增加水摄入量的受试者获得的尿液极大地增加了初始沉积速率和粘附的E。coli和E.粪肠球菌（P < 0.05）。
In this study, urine was collected from groups of volunteers following the consumption of water, ascorbic acid, or cranberry supplements. Only ascorbic acid intake consistently produced acidic urine. Photospectroscopy data indicated that increased water consumption produced urine with lower protein content. Surface tension measurements of the collected urine showed that both water and cranberry supplementation consistently produced urine with surface tensions higher than the control or urine collected following ascorbic acid intake. These urine samples were also employed to study uropathogen adhesion to silicone rubber in a parallel plate flow chamber. Urine obtained after ascorbic acid or cranberry supplementation reduced the initial deposition rates and numbers of adherent Escherichia coli and Enterococcus faecalis, but not Pseudomonas aeruginosa, Staphylococcus epidermidis, or Candida albicans. Conversely, urine obtained from subjects with increased water intake vastly increased the initial deposition rates and numbers of adherent E. coli and E. faecalis (P < 0.05).