Genetic variation on chromosome 9p21 shows association with the ischaemic stroke subtype large-vessel disease in a Swedish sample aged ≤70
Genetic variation on chromosome 9p21 shows association with the ischaemic stroke subtype large-vessel disease in a Swedish sample aged ≤70
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DOI：
10.1111/j.1468-1331.2010.03096.x
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发表时间：
2011-02-01
影响因子：
5.1
通讯作者：
Jern, C.
中科院分区：
文献类型：
--
作者：
Olsson, S.;Jood, K.;Jern, C.
背景：本研究的目的是调查我们是否可以复制最近发现的染色体9p21上的遗传变异与缺血性卒中（IS）亚型大血管疾病（LVD）之间的关联。方法：Sahlovska学院对缺血性卒中的研究包括844例IS患者，他们在70岁之前患有IS，668例健康对照。IS亚型根据吐司标准进行定义，111例患者被归类为LVD。分析了9p21上的7个单核苷酸多态性（SNPs）。IS后3个月采用改良兰金量表评估功能结局。结果：SNP rs7857345与LVD亚型显著相关，独立于传统的血管危险因素。此外，rs7857345和LVD后的功能结果之间的关联observed.Conclusion：在这个相对年轻的样本与IS患者，9p21的遗传变异与LVD。
Background:The aim of this study was to investigate whether we could replicate a recent finding of an association between genetic variants on chromosome 9p21 and the ischaemic stroke (IS) subtype large-vessel disease (LVD).Methods:The Sahlgrenska Academy Study on Ischemic Stroke comprises 844 patients with IS, who suffered IS before reaching the age of 70, and 668 healthy controls. IS subtype was defined according to the TOAST criteria, and 111 patients were categorized as LVD. Seven single-nucleotide polymorphisms (SNPs) on 9p21 were analyzed. Functional outcome was assessed 3 months after IS using the modified Rankin scale.Results:The SNP rs7857345 showed a significant association with the subtype LVD independent of traditional vascular risk factors. In addition, an association between rs7857345 and functional outcome after LVD was observed.Conclusion:In this relatively young sample of patients with IS, genetic variation on 9p21 is associated with LVD.