Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass
Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass
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DOI：
10.1016/s0928-0987(02)00245-2
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发表时间：
2003-01-01
影响因子：
4.6
通讯作者：
Bernkop-Schnürch, A
中科院分区：
文献类型：
--
作者：
Leitner, VM;Marschütz, MK;Bernkop-Schnürch, A
本研究的目的是评估分子量和相应的聚合物链长对硫醇化聚合物的粘膜粘附和内聚的影响。线性聚2-、45-、250-和450 kDa的（丙烯酸）-半胱氨酸（PAA-Cys）缀合物（PAA（2）-CYS、PAA（45）-CYS、PAA（250）-Cys和PAA（450）-Cys）和聚卡非体-半胱氨酸（PCP-Cys，750-3000 kDa），所有均显示平均404.1 +/-65.5 μ Mol硫醇基团/克聚合物，将其压制成片剂以进行崩解试验，粘膜粘附研究和粘度测量。此外，评价了游离的未结合的半胱氨酸对粘膜粘附的影响。崩解试验显示片剂的稳定性如下：PAA（2）-Cys
The objective of this study was to evaluate the influence of the molecular mass and accordingly the polymer chain length on mucoadhesion and cohesion of thiolated polymers. Linear poly(acrylic acid)-cysteine (PAA-Cys) conjugates of 2-, 45-, 250- and 450 kDa (PAA(2)-CYS, PAA(45)-CYS, PAA(250)-Cys and PAA(450)-Cys) and polycarbophil-cysteine (PCP-Cys, 750-3000 kDa), all displaying on average 404.1 +/- 65.5 muMol thiol groups per gram polymer were compressed into tablets to perform disintegration tests, mucoadhesion studies and viscosity measurements. Moreover, the influence of free unbound cysteine on mucoadhesion was evaluated. Disintegration tests showed a stability of the tablets as following: PAA(2)-Cys