Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients
Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients
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DOI：
10.1016/j.jad.2009.12.022
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发表时间：
2010-08-01
影响因子：
6.6
通讯作者：
Giraldi, Tullio
中科院分区：
文献类型：
--
作者：
Grassi, Luigi;Rossi, Elena;Giraldi, Tullio
背景：在普通人群和内科疾病患者中，混合证据表明，5-羟色胺转运体基因连锁多态区域(5-HTTLPR)短等位基因纯合携带者(S/S)与长等位基因携带者(L/L)或S/L相比，可能增加抑郁的风险。鉴于肿瘤学数据的缺乏，我们研究了乳腺癌患者抑郁与5-HTTLPR及心理社会变量的关系。方法：对145例乳腺癌患者的抑郁、心理社会相关变量(应对方式、D型人格、生活事件和社会支持)进行研究。结果：S/S、S/L和L/L患者在抑郁及其他心理社会变量方面差异无统计学意义。未观察到5-HITLPR与近期生活事件之间的基因-环境(G×E)交互作用。结论：本研究未支持5-HTTLPR基因多态单独或与生活事件一起与初诊乳腺癌患者抑郁的可能关联。然而，需要进一步的后续研究来证实这些数据。(C)2009年，爱思唯尔出版。
Background: Mixed evidence in the general population and medically ill patients has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may increase the risk of depression in comparison with carriers of the long allele (l/l) or s/l. Given the lack of data in oncology, we examined the relationship of depression with the 5-HTTLPR and psychosocial variables among breast cancer patients.Methods: A sample of 145 breast cancer patients were studied as regards to depression, psychosocial-related variables (coping, Type D-personality, life events, and social support), and the 5-HTFLPR, which was genotyped by using a standard protocol with DNA extracted from the blood.Results: No difference was found between s/s, s/l and l/l patients on depression and any other psychosocial variable. No gene-by environment (G x E) interactions were observed between the 5-HITLPR and recent life events.Conclusions: The study did not provide support of a possible association between 5-HTTLPR polymorphism, alone or in conjunction with life events, and depression in newly diagnosed breast cancer. Further follow-up studies are however necessary to confirm these data. (C) 2009 Published by Elsevier B.V.