Affective temperaments: Familiality and clinical use in mood disorders
Affective temperaments: Familiality and clinical use in mood disorders
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DOI：
10.1016/j.jad.2012.11.047
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发表时间：
2013-05-15
影响因子：
6.6
通讯作者：
Correa, Humberto
中科院分区：
文献类型：
--
作者：
Ferriera, Alexandre de Aguiar;Vasconcelos, Alina Gomide;Correa, Humberto
背景：情绪障碍患者的情感气质特征可能是这些患者临床评估的重要参数。有人提出，气质特征具有家族性，并且可能代表脆弱性标记，以识别发生特定临床类型情绪障碍的风险。为了检验这些理论，我们对双相情感障碍患者 (BP)、单相重性抑郁患者 (UP)、这些患者的健康亲属 (HRP) 和正常对照 (NC) 进行了气质测量。方法：我们使用巴西版 TEMPSA TEMPS-里约热内卢的简短巴西版本，比较了 90 BP、88 UP、132 HRP 和 136 NC 之间的情感气质得分。构建了 MANCOVA 模型。因变量是 TEMPS-RJ 的六个子量表（抑郁、循环性、易怒、亢奋、焦虑和担忧气质）。年龄和性别的影响作为协变量进行了调整。此外，我们还对 68 名 HRP、双相情感障碍患者亲属 (HRBP) 和其余 64 名 HRP、单相情感障碍患者亲属 (HRUP) 和对照组进行了比较。 结果：除心境亢进评分外，临床组（BP、UP）的气质评分高于 NC。与 UP 相比，BP 表现出更高的循环气质 (p < 0.001)、亢奋气质 (p < 0.001) 和较低的焦虑气质 (p < 0.01)。 HRP 显示分数低于临床组。 HRBP的循环情感分量表得分高于HRUP和NC组。局限性：双相I和II受试者被置于同一组。结论：循环情感和高情感特征与患者的双相情感障碍相关，循环情感气质可能是双相情感障碍患者健康亲属的特征性特征。我们的数据支持情感气质可能成为情绪障碍临床评估和研究目的的有用工具。 (C) 2012 Elsevier B.V. 保留所有权利。
Background: The affective temperament profiles among patients with mood disorders may be an important parameter in the clinical evaluation of these patients. It has been proposed that temperament traits have familiality and may represent vulnerability markers to identify the risk to developing specific clinical type of mood disorders. To test these theories, measures of temperament were examined in bipolar patients (BP), unipolar major depressive patients (UP), healthy relatives of these patients (HRP) and normal controls (NC).Methods: We compared affective temperament scores, using the brief Brazilian version of TEMPSA TEMPS-Rio de Janeiro, between 90 BP, 88 UP, 132 HRP and 136 NC. A MANCOVA model was constructed. Dependent variables were the six subscales of the TEMPS-RJ (depressive, cyclothymic, irritable, hyperthymic, anxious and worrying temperaments). The effects of age and gender were adjusted as covariates. Furthermore, we performed a comparison between a subgroup of 68 HRP, relatives of bipolar patients (HRBP), and the remainders 64 HRP, relatives of unipolar patients (HRUP) and controls.Results: The clinical group (BP, UP) showed higher temperament scores than NC, except for hyperthymic scores. BP showed higher cyclothymic (p < 0.001), hyperthymic (p < 0.001) and lower anxious (p < 0.01) temperament scores than UP. HRP showed lower scores than clinical groups. HRBP scored higher cyclothymic subscale than HRUP and NC groups.Limitations: Bipolar I and II subjects were placed in the same group.Conclusions: The cyclothymic and hyperthymic traits were associated with bipolarity in patients and cyclothymic temperament could be a characteristic trait of the healthy relatives of bipolar patients. Our data support that affective temperament might become a useful tool for clinical evaluation and research purposes in mood disorders. (C) 2012 Elsevier B.V. All rights reserved.