Effects of heparin on lipolytic enzyme activities in vivo and in vitro.
Effects of heparin on lipolytic enzyme activities in vivo and in vitro.
复制标题
肝素对体内和体外脂肪分解酶活性的影响。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
A. Howard
中科院分区：
文献类型：
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作者：
J. Patelski;Z. Waligóra;A. Howard
研究了肝素对正常兔血清和组织中脂肪分解酶活性的体内和体外影响。急性静脉注射肝素后，酶活性发生如下变化：血清中磷脂酶和脂肪酶升高，胆固醇酯酶不变；组织中磷脂酶升高，心脏和肝脏脂肪酶升高，主动脉降低，心脏胆固醇酯酶升高，肝脏和主动脉降低。体外磷脂酶和脂肪酶随低浓度肝素升高而升高，但随高浓度肝素降低。无论肝素浓度如何，胆固醇酯酶都会降低。这表明肝素可能通过影响酶和底物的离子状态来影响脂肪分解酶的活性。
The in vivo and in vitro effects of heparin on the lipolytic enzyme activities of normal rabbit serum and tissues were investigated. An acute intravenous injection of heparin produced the following changes in enzyme activities: in serum, phospholipase and lipase were increased, cholesterol esterase unchanged; in tissues phospholipase was increased, lipase was increased in heart and liver but decreased in aorta, cholesterol esterase was increased in heart but decreased in liver and aorta. In vitro phospholipase and lipase were increased by low concentrations of heparin, but decreased by high concentrations. Cholesterol esterase was decreased irrespective of heparin concentration. It is suggested that heparin may affect lipolytic enzyme activities by influencing the ionic state of the enzyme and substrate.