The SWAN biomedical discourse ontology
The SWAN biomedical discourse ontology
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DOI：
10.1016/j.jbi.2008.04.010
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发表时间：
2008-10-01
影响因子：
4.5
通讯作者：
Clark, Tim
中科院分区：
文献类型：
--
作者：
Ciccarese, Paolo;Wu, Elizabeth;Clark, Tim
开发针对神经退行性疾病等高度复杂疾病的治疗方法，需要广泛的跨学科合作和生物医学信息的交流。当今，我们跨亚专业交换此类信息的能力受到当前科学知识生态系统无法以机器可解释的形式正确背景化和整合数据和话语的限制。这本质上限制了研究的生产力和治疗阿尔茨海默氏症和帕金森氏症等毁灭性疾病的进展。SWAN（神经医学语义网应用）是一个跨学科项目，旨在开发一个实用的、通用的、语义结构的生物医学话语框架，最初应用于但不限于阿尔茨海默病（AD）研究中的重大问题。SWAN本体是在为生物医学研究人员构建一系列应用程序的背景下开发的，以及与生物医学研究人员的广泛讨论和合作。更大的生物本体社区。在本文中，我们提出并讨论了生物医学话语的 SWAN 本体。我们从理论上奠定其发展的基础，介绍其设计方法，解释其主要类别及其应用，并展示其与生物医学和生物本体论中其他正在进行的活动的关系。 (C) 2008 Elsevier Inc. 保留所有权利。
Developing cures for highly complex diseases, such as neurodegenerative disorders, requires extensive interdisciplinary collaboration and exchange of biomedical information in context.Our ability to exchange such information across sub-speciaities today is limited by the Current scientific knowledge ecosystem's inability to properly contextualize and integrate data and discourse in machine-interpretable form. This inherently limits the productivity of research and the progress toward cures for devastating diseases Such as Alzheimer's and Parkinson's.SWAN (Semantic Web Applications in Neuromedicine) is an interdisciplinary project to develop a practical, common, semantically structured, framework for biomedical discourse initially applied, but not limited, to significant problems in Alzheimer Disease (AD) research.The SWAN ontology has been developed in the context of building a series of applications for biomedical researchers, as well as in extensive discussions and collaborations with the larger bio-ontologies community.In this paper, we present and discuss the SWAN ontology of biomedical discourse. We ground its development theoretically, present its design approach, explain its main classes and their application, and show its relationship to other ongoing activities in biomedicine and bio-ontologies. (C) 2008 Elsevier Inc. All rights reserved.