Plasma extracellular superoxide dismutase and erythrocyte Cu,Zn-containing superoxide dismutase in alcoholics treated with disulfiram.
Plasma extracellular superoxide dismutase and erythrocyte Cu,Zn-containing superoxide dismutase in alcoholics treated with disulfiram.
复制标题
用双硫仑治疗的酗酒者血浆细胞外超氧化物歧化酶和红细胞含铜、锌超氧化物歧化酶。
作者：
Michael Öhman;Stefan L. Marklund
Disulfiram has long been used in the treatment of chronic alcoholism. It is in vivo partially reduced to diethyldithiocarbamate, which is an efficient inhibitor of Cu,Zn-containing superoxide dismutase both in vitro and in vivo. The recently described extracellular superoxide dismutase is even more sensitive to diethyldithiocarbamate than Cu,Zn-superoxide dismutase. To test for the possibility that long term treatment with disulfiram leads to inhibiton of the superoxide dismutases, plasma extracellular superoxide dismutase and erythrocyte Cu,Zn-superoxide dismutase were determined in 12 disulfiram-treated alcoholics, and compared with 11 non-treated alcoholics and 19 healthy controls. Plasma extracellular superoxide dismutase was moderately reduced (about 20%) in the disulfiram-treated alcoholics as compared with the non-treated alcoholics and the healthy controls. No effect of disulfiram treatment on erythrocyte Cu,Zn-superoxide dismutase activity was demonstrated.
