Relationship between visceral fat accumulation and anti-lipolytic action of insulin in patients with type 2 diabetes Mellitus
Relationship between visceral fat accumulation and anti-lipolytic action of insulin in patients with type 2 diabetes Mellitus
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DOI：
10.1507/endocrj.49.459
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发表时间：
2002-08-01
影响因子：
2
通讯作者：
Kato, Y
中科院分区：
文献类型：
--
作者：
Kurioka, S;Murakami, Y;Kato, Y
胰岛素抵抗与2型糖尿病的发生密切相关。内脏脂肪堆积与胰岛素抵抗有关，胰岛素抵抗会影响游离脂肪酸（FFA）代谢。我们研究了 20 名 2 型糖尿病患者（包括 11 名肥胖受试者和 9 名非肥胖受试者）的内脏脂肪积累、FFA 代谢和胰岛素抵抗之间的相互作用。通过腹部计算机断层扫描测量脐部皮下和内脏脂肪量的面积来估计身体脂肪分布。在正常血糖高胰岛素钳夹研究中，将葡萄糖输注率（GIR）和血浆 FFA 对胰岛素的反应分别确定为胰岛素抵抗和抗脂肪分解作用的指标。在所有糖尿病患者中，GIR 与胰岛素诱导的血浆 FFA 降低呈负相关（r=-0.652，P
Insulin resistance is closely related to developing type 2 diabetes mellitus. Visceral fat accumulation is associated with insulin resistance, which affects the free fatty acid (FFA) metabolism. We investigated the interactions among visceral fat accumulation, FFA metabolism and insulin resistance in 20 patients with type 2 diabetes mellitus, including 11 obese and 9 non-obese subjects. Body fat distribution was estimated by measuring the areas of both subcutaneous and visceral fat mass on abdominal computed tomography at the umbilical level. Glucose infusion rate (GIR) and plasma FFA responses to insulin were determined as an index of insulin resistance and anti-lipolytic action, respectively, in a euglycemic hyperinsulinemic clamp study. There was an inverse correlation between GIR and insulin-induced decrease in plasma FFA in all diabetic patients (r=-0.652, P