GENDER AND CHRONIC STRESS EFFECTS ON THE NEURAL RETINA OF YOUNG AND MID-AGED FISCHER-344 RATS
GENDER AND CHRONIC STRESS EFFECTS ON THE NEURAL RETINA OF YOUNG AND MID-AGED FISCHER-344 RATS
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DOI：
10.1016/0197-4580(87)90040-6
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发表时间：
1987-09-01
影响因子：
4.2
通讯作者：
BRODISH, A
中科院分区：
文献类型：
--
作者：
OSTEEN, WK;SWEATT, AJ;BRODISH, A
将幼年（5个月）和中年（11个月）雄性和雌性Fischer大鼠每天（每周5天）暴露于慢性可逃避性足震应激6个月。在随后的1个月的休息期，即动物12个月和18个月大时，对神经视网膜进行组织病理学和形态计量学评估。与年轻的动物相比，中年动物的视网膜厚度明显减少。与年龄相关的严重的感光细胞损失，尤其是视网膜周围区域的感光细胞损失，其模式类似于人类衰老的模式。压力的影响是以类似于年龄相关的细胞损失的模式增加光感受器的损失。在两个年龄段的男性和女性中都观察到与压力相关的光感受器细胞死亡，但在中年男性中更为明显和具有统计学意义（细胞损失比女性增加了5倍）。结果表明，暴露于慢性可逃避性足震应激的大鼠加剧了通常与衰老相关的视网膜变化，并且慢性应激暴露的有害影响在老年雄性组中更大。
Young (5 months) and mid-aged (11 months) male and female Fischer rats were exposed to daily (5 days/week) chronic escapable foot-shock stress for 6 months. Following a subsequent 1-month rest period, by which time the animals were 12 and 18 months old, neural retinas were evaluated histopathologically and morphometrically. A significant reduction in the thickness of the retina occurred in the mid-aged, as compared to the young animals. A severe age-related loss in photoreceptor cells, particularly in the peripheral zones of the retina, occurred in a pattern resembling that described for aging humans. The effect of stress was to increase photoreceptor loss in a pattern resembling that of age-related cell loss. Stress-associated photoreceptor cell death was observed in males and females of both ages, but was more pronounced and statistically significant for mid-aged males (a five-fold increase in cell loss over females). The results demonstrated that exposure of rats to chronic escapable foot-shock stress exacerbates retinal changes commonly associated with aging and that the deleterious effects of chronic stress exposure were greater in the older age, male group.