Consider the Tidemark
Consider the Tidemark
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DOI：
10.3899/jrheum.110942
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
P. Simkin
中科院分区：
文献类型：
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作者：
P. Simkin
作为正常成人关节软骨最显著的组织学特征，潮标值得我们去了解。在他们最初的描述中，Fawns和Landells将这一地标比作现在退潮的高点在沙滩上留下的不规则的碎片线1（图1A）。这种潮标由海洋漂浮物的混合物组成，因此包含了各种各样的海洋物质。如果软骨的潮标被恰当地命名，我相信它是，它也应该是一个被动的存款的碎片，但它的成分是什么，他们从哪里来？图1. a.美国俄勒冈州曼萨尼塔的海滩上的潮标。B。马洛里苯胺蓝染色的潮标在正常人掌指骨（MCP）关节。注意细胞核和潮标共有基质中未观察到的橙子染色。这张图片，以及下面的图片，来自一个没有风湿性疾病的老年人，他的身体是通过华盛顿大学的意志身体项目捐赠给解剖学研究的。c和d. 1例MCP关节第一节指骨基底和掌骨头的Von Gieson染色。里昂等人强调了此处所见的三层结构10。它的基础仍然无法解释。在掌骨头部看到的潮标重复通常被认为是骨关节炎的证据。e.莫瓦特染色。潮标粒度（？凋亡小体）的研究在Fawns和Landells的经典报道中有描述1。F.马森三色染色。再次注意，在所有章节中，.. Simkin，美国华盛顿大学医学系，356428信箱，美国华盛顿98195。电子邮件：psimkin {at} uw.edu
As the most conspicuous histologic feature of normal adult articular cartilage, the tidemark begs for our understanding. In their original description, Fawns and Landells likened this landmark to the irregular line of debris that is left on a sandy beach by the high point of a now-receding tide1 (Figure 1A). Such tidemarks comprise a mixture of marine flotsam, and so contain a variety of stuff from the sea. If the tidemark of cartilage is aptly named, as I believe it to be, it too should be a passive deposit of debris, but what are its constituents and where do they come from? Figure 1. A. A tidemark on the beach at Manzanita, Oregon, USA. B. Mallory aniline blue stain of the tidemark in a normal human metacarpal phalangeal (MCP) joint. Note that cell nuclei and the tidemark share orange staining not seen in the matrix. This image, as well as those that follow, was from an older subject without known rheumatic disease whose body was donated for anatomic study through the willed body program at the University of Washington. C and D. Von Gieson stains of first phalanx base and metacarpal head from 1 MCP joint. The trilaminar structure seen here was stressed by Lyons, et al 10. Its basis remains unexplained. The tidemark duplication seen in the metacarpal head is generally considered to be evidence of osteoarthritis. E. Mowat stain. Granularity of the tidemark (? apoptotic bodies) was described in the classic report of Fawns and Landells1. F. Masson trichrome stain. Again note that, as in all sections, … Address correspondence to Dr. P.A. Simkin, Division of Rheumatology, Box 356428, Department of Medicine, University of Washington, Seattle, Washington 98195, USA. E-mail: psimkin{at}uw.edu