Cytokine profiles in crevicular fluid during orthodontic tooth movement of short and long durations
Cytokine profiles in crevicular fluid during orthodontic tooth movement of short and long durations
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DOI：
10.1902/jop.2007.060261
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发表时间：
2007-03-01
影响因子：
4.3
通讯作者：
de Vos, Paul
中科院分区：
文献类型：
--
作者：
Ren, Yijin;Hazemeijer, Heleen;de Vos, Paul
背景资料：正畸治疗诱导牙周组织细胞外基质的变形，导致细胞骨架结构的改变。已知细胞因子通过诱导细胞增殖、分化和刺激牙周重塑来促进这一过程。本研究的目的是测量一个面板的促炎细胞因子（PIC）在龈沟液（GCF）样品在牙齿移动的短期和长期的持续时间。方法：12例（11至27岁）参加了这项研究：6例患者的短期和长期的牙齿移动。GCF采样在不同时间进行，范围从施力后24小时至4个月。结果：在牙移动的早期，牙槽嵴嵴白细胞介素（IL）-1 β和-6和肿瘤坏死因子-α（TNF-α）在24小时达到显著水平; IL-8在1个月时达到显著升高。在牙齿移动的线性阶段，所有细胞因子均降低至基线水平。结果表明，IL-1 β，-6，和-8和TNF-α在牙齿移动的早期阶段发挥了重要作用，但不是在线性stage.Conclusions：一旦牙周组织的微环境被激活的正畸力，几个关键的PIC产生触发级联的细胞事件。牙周系统稳定在一个新的生理稳态，如所示的下调的早期阶段PIC。
Background: Orthodontic treatment induces a distortion of the extracellular matrix of the periodontium, resulting in alterations in cytoskeletal configuration. Cytokines are known to facilitate this process by inducing cellular proliferation, differentiation, and stimulation of periodontal remodeling. The aim of the present study was to measure a panel of proinflammatory cytokines (PICs) in crevicular fluid (GCF) samples during tooth movement of short and long durations.Methods: Twelve patients (11 to 27 years of age) participated in this study: six patients each for tooth movement of short and long duration. GCF sampling was done at different times, ranging from 24 hours to 4 months after force application. The profiles of PICs were analyzed with a multiplex technique.Results: PICs were elevated significantly in the early stage of tooth movement but at different time points. Interleukin (IL)-1 beta and -6 and tumor necrosis factor-alpha (TNF-alpha) reached significant levels at 24 hours; IL-8 reached a significant elevation at I month. During the linear stage of tooth movement, all cytokines were diminished to their baseline levels. The results demonstrated that IL-1 beta, -6, and -8 and TNF-alpha play a significant role during the early stage of tooth movement but not during the linear stage.Conclusions: Once the microenvironment of periodontal tissue is activated by an orthodontic force, several key PICs are produced to trigger a cascade of cellular events. The periodontal system stabilizes at a new physiological homeostasis as indicated by the downregulation of the early-phase PICs.