Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004
Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004
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DOI：
10.1093/aje/kwn414
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发表时间：
2009-04-15
影响因子：
5
通讯作者：
Guallar, Eliseo
中科院分区：
文献类型：
--
作者：
Bleys, Joachim;Navas-Acien, Ana;Guallar, Eliseo
作者对参加 2003-2004 年国家健康和营养检查调查的 2,062 名 40 岁或以上的美国男性和女性进行了血清硒与外周动脉疾病患病率之间关系的横断面研究。使用电感耦合等离子体动力反应池质谱法测量血清硒。外周动脉疾病定义为踝臂血压指数<0.90。经年龄、性别和种族调整后的外周动脉疾病患病率随着血清硒含量的增加而降低（线性趋势 P = 0.02），但有迹象表明血清硒含量最高四分位数的风险有所上升。将硒四分位数 2、3 和 4 与最低四分位数进行比较，完全调整后的外周动脉疾病比值比分别为 0.75（95% 置信区间：0.37、1.52）、0.58（95% 置信区间：0.28、1.19）和 0.67（95% 置信区间：0.34、1.31）。在样条回归模型中，随着血清硒水平增加至 150-160 ng/mL，外周动脉疾病患病率下降，随后在较高硒水平下逐渐增加。尽管有人认为存在 U 形关系，但血清硒水平与外周动脉疾病患病率之间的相关性并不具有统计学意义。
The authors conducted a cross-sectional study of the association of serum selenium with the prevalence of peripheral arterial disease among 2,062 US men and women 40 years of age or older participating in the National Health and Nutrition Examination Survey, 2003-2004. Serum selenium was measured by using inductively coupled plasma-dynamic reaction cell-mass spectrometry. Peripheral arterial disease was defined as an ankle-brachial blood pressure index < 0.90. The age-, sex-, and race-adjusted prevalence of peripheral arterial disease decreased with increasing serum selenium (P for linear trend = 0.02), but there was an indication of an upturn in risk in the highest quartile of serum selenium. The fully adjusted odds ratios for peripheral arterial disease comparing selenium quartiles 2, 3, and 4 with the lowest quartile were 0.75 (95% confidence interval: 0.37, 1.52), 0.58 (95% confidence interval: 0.28, 1.19), and 0.67 (95% confidence interval: 0.34, 1.31), respectively. In spline regression models, peripheral arterial disease prevalence decreased with increasing serum selenium levels up to 150-160 ng/mL, followed by a gradual increase at higher selenium levels. The association between serum selenium levels and the prevalence of peripheral arterial disease was not statistically significant, although a U-shaped relation was suggested.