Identification of heavy drinkers by using the early detection of alcohol consumption score
Identification of heavy drinkers by using the early detection of alcohol consumption score
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DOI：
10.1111/j.1530-0277.2001.tb02203.x
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发表时间：
2001-02-01
影响因子：
3.2
通讯作者：
Bean, P
中科院分区：
文献类型：
--
作者：
Harasymiw, JW;Bean, P
背景资料：本研究的目的是评估使用常规血液化学和血液学检查，以检测重度饮酒者在门诊受试者。重度饮酒者被定义为在样本采集前至少1个月内，男性平均每天饮用4杯或更多标准饮料，女性平均每天饮用3杯或更多标准饮料的受试者（1标准饮料= 15 ml无水乙醇）。常规血液化学小组和年龄，性别，用线性判别函数（LDF）分析将受试者分为重度饮酒者和轻度饮酒者。通过与标准化问卷和访谈建立的饮酒模式进行比较，验证了分类。受试者（n = 807）是男性和女性，从25个中心，包括戒毒和康复机构，教堂，社区团体在密尔沃基和波士顿areas.Results招募已知的饮酒模式：与LDF，88%的重度饮酒者和92%的轻度饮酒者被正确识别的酒精消费测试的早期检测。LDF在用于识别30岁及以上的重度饮酒时表现最好，该组显示出84%（143人中的120人）的灵敏度和97%（157人中的152人）的特异性。在雌性动物中的表现显示73%（76/103）的灵敏度和94%（129/137）的特异性，高于先前检查的任何单一生化标志物。受试者工作特征图分析显示女性曲线下面积为0.94，男性曲线下面积为0.95（p < 0.0001）。结论：酒精消费评分的早期检测是一个实用的实验室屏幕检测大量饮酒的基础上，定期在临床设置的血液成分。
Background: The objective of this study was to evaluate the use of routine blood chemistry and hematology tests to detect heavy drinkers among ambulatory subjects. Heavy drinkers were defined as subjects who consumed an average of four or more standard drinks per day if male and an average of three or more standard drinks per day if female, for at least 1 month before sample collection (1 standard drink = 15 ml of absolute ethanol).Methods: A routine blood chemistry panel and the demographic factors of age, sex, and ethnicity were evaluated by using linear discriminant function (LDF) analysis to classify subjects as heavy drinkers dr light drinkers. The classification was validated by comparison with drinking patterns established by standardized questionnaire and interview. Subjects (n = 807) were males and females with known drinking patterns recruited from 25 centers that included detoxification and rehabilitation institutions, churches, and community groups in the Milwaukee and Boston areas.Results: With LDF, 88% of the heavy drinkers and 92% of the light drinkers were correctly identified by the Early Detection of Alcohol Consumption test. The LDF performed the best when used to identify heavy drinking in ages 30 and above, a group that showed 84% (120 of 143) sensitivity at 97% (152 of 157) specificity. Performance in females showed 73% (76 of 103) sensitivity at 94% (129 of 137) specificity, rates higher than obtained with any single biochemical marker previously examined. Receiver operating characteristic plot analysis showed areas under the curve of 0.94 for females and 0.95 for males (p < 0.0001).Conclusions: The Early Detection of Alcohol Consumption score is a practical laboratory screen for detecting heavy drinking based on blood constituents ordered routinely in clinical settings.