Time to Mycoplasma Pneumoniae RNA Clearance for Wheezy vs. Non-Wheezy Young Children with Community-Acquired Pneumonia
Time to Mycoplasma Pneumoniae RNA Clearance for Wheezy vs. Non-Wheezy Young Children with Community-Acquired Pneumonia
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DOI：
10.1093/tropej/fmaa109
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发表时间：
2021-02-01
影响因子：
2
通讯作者：
Yuan, Shuhua
中科院分区：
文献类型：
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作者：
Chen, Jiande;Ji, Fengjuan;Yuan, Shuhua
目的：我们旨在调查社区获得性肺炎（CAP）住院幼儿中肺炎支原体（Mp）RNA的动态，并探讨阿奇霉素治疗开始后，喘息组和非喘息组的Mp RNA清除率是否存在差异。方法：我们纳入了由Mp感染引起的CAP住院幼儿（1-72月龄）。患者入院后立即检测Mp RNA，并在开始阿奇霉素治疗第4、7、14和28天后监测Mp-RNA动态。结果：40例住院的肺炎支原体肺炎（Mpp）幼儿中，16例出现喘息。喘息组（中位 7 天，四分位距 7-10.5）和非喘息组（中位 7 天，四分位距 5.8-8.3）在 Mpp 症状出现后首次确认 Mp-RNA 阳性的时间相似。阿奇霉素治疗开始后，喘息组中 Mp-RNA 检测呈阳性的持续时间短于非喘息组（中位 4 天与 7 天；风险比 2.083；95% 置信区间：1.023-4.244）。 结论：出现喘息的 Mpp 幼儿中 Mp-RNA 清除速度明显快于无喘息组。阿奇霉素治疗。小结我们旨在调查社区获得性肺炎住院幼儿中肺炎支原体 (Mp) RNA 的动态，并探讨阿奇霉素治疗开始后，喘息组和非喘息组的 Mp RNA 清除率是否存在差异。我们的研究表明，在阿奇霉素治疗开始后，有喘息的肺炎支原体肺炎幼儿的 Mp-RNA 清除速度明显快于没有喘息的幼儿。
Objectives: We sought to investigate the dynamics of Mycoplasma pneumoniae (Mp) RNA in hospitalized young children with community-acquired pneumonia (CAP) and to explore whether Mp RNA clearance differed for wheezy and non-wheezy group after the onset of azithromycin treatment.Methods: We included hospitalized young children (1-72 months of age) with CAP caused by Mp infection. Mp RNA was detected as soon as the patient was admitted and the dynamics of Mp-RNA were monitored after the beginning of azithromycin treatment on Days 4, 7, 14 and 28.Results: Among 40 hospitalized young children with Mycoplasma pneumoniae pneumonia (Mpp), 16 had wheezing. Time to first positive Mp-RNA confirmation after symptom onset of Mpp was similar for the wheezy group (median 7 days, interquartile range 7-10.5) and the non-wheezy group (median 7 days, interquartile range 5.8-8.3). The duration of positive Mp-RNA detection after the onset of azithromycin treatment was shorter among the wheezy group than in the non-wheezy group (median 4 vs. 7 days; hazard ratio 2.083; 95% confidence interval: 1.023-4.244).Conclusions: Mp-RNA clearance was significantly faster among Mpp young children with wheezing than in those without wheezing after the onset of azithromycin treatment.LAY SUMMARYWe sought to investigate the dynamics of Mycoplasma pneumoniae (Mp) RNA in hospitalized young children with community-acquired pneumonia and to explore whether Mp RNA clearance differed for wheezy and non-wheezy group after the onset of azithromycin treatment. Our study suggested that Mp-RNA clearance was significantly faster among Mycoplasma pneumoniae pneumonia young children with wheezing than in those without wheezing after the onset of azithromycin treatment.