First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes
First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes
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DOI：
10.1007/s00125-002-0981-8
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发表时间：
2002-12-01
期刊：
影响因子：
8.2
通讯作者：
Simell, O
中科院分区：
文献类型：
--
作者：
Keskinen, P;Korhonen, S;Simell, O
目的/假说。在I型（胰岛素依赖型）糖尿病的发展过程中，静脉注射葡萄糖的第一阶段胰岛素反应降低被认为是β细胞功能严重恶化的迹象，但缺乏糖尿病相关自身免疫发病时胰岛素反应的数据。我们研究了观察到血清转化为自身抗体阳性后不久的幼儿一期胰岛素反应。在I型糖尿病预测和预防研究中，对新生儿进行hla - dqb1相关的I型糖尿病遗传风险筛查，并对风险增加的新生儿进行胰岛细胞抗体的随访。如果检测到抗体，还测量针对其他三种抗原（胰岛素、GAD65和IA-2）的自身抗体。为了测量第一阶段胰岛素反应，对52例（1 ~ 5岁）最近血清转化为胰岛细胞抗体阳性的儿童进行了静脉葡萄糖耐量试验。第一阶段胰岛素反应低于正常(
Aims/hypothesis. A reduced first-phase insulin response to intravenous glucose is perceived as a sign of far-advanced deterioration of beta-cell function during the development of Type I (insulin-dependent) diabetes mellitus, but data on insulin responses at the onset of diabetes-related autoimmunity are lacking. We studied the first-phase insulin responses of small children soon after observed seroconversion to autoantibody positivity.Methods. In the Type I Diabetes Prediction and Prevention Study newborn infants are screened for HLA-DQB1-associated genetic risk for Type I diabetes and those with increased risk are followed-up for the emergence of islet-cell antibodies. If antibodies are detected, autoantibodies to three other antigens (insulin, GAD65 and IA-2) are also measured. To measure first-phase insulin responses, intravenous glucose tolerance tests were carried out in 52 (1 to 5-year-old) children who had recently seroconverted to islet-cell antibody positivity.Results. The first-phase insulin response was subnormal (