MESOLIMBIC DOPAMINERGIC-NEURONS AND SOMATO-DENDRITIC MECHANISMS
MESOLIMBIC DOPAMINERGIC-NEURONS AND SOMATO-DENDRITIC MECHANISMS
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DOI：
10.1016/0304-3940(79)96107-x
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发表时间：
1979-01-01
影响因子：
2.5
通讯作者：
GUNDLACH, AL
中科院分区：
文献类型：
--
作者：
BEART, PM;MCDONALD, D;GUNDLACH, AL
通过对中边缘多巴胺能神经元的研究，探讨了神经元可以从树突和轴突两个部位释放递质的概念。大鼠腹侧被盖（包含中边缘多巴胺能神经元的树突和体）具有高水平的多巴胺和酪氨酸羟化酶。升高钾（44 mM）后，腹侧被盖片积累[3H]多巴胺（15或60 nM），并观察刺激诱导的[3H]多巴胺释放。钾诱导的释放是钙依赖的。这些多巴胺能参数与伏隔核（包含中脑边缘多巴胺能神经元的末端）的参数进行了比较。硫硝嗪和氯氮平可使腹侧被盖3,4-二羟基苯乙酸（DOPAC）浓度升高。
The concept that a neurone may release transmitter from both dendritic and axonal sites was investigated by studying mesolimbic dopaminergic neurones. The rat ventral tegmentum (containing dendrites and somata of mesolimbic dopaminergic neurones) possessed high levels of dopamine and tyrosine hydroxylase. Slices of ventral tegmentum accumulated [3H]dopamine (15 or 60 nM) and stimulus-induced release of [3H]dopamine was observed after elevated potassium (44 mM). The potassium-induced release was calcium-dependent. These dopaminergic parameters were compared to those found for nucleus accumbens (containing terminals of mesolimbic dopaminergic neurones). Thioridazine and clozapine elevated 3,4-dihydroxyphenylacetic acid (DOPAC) concentration in ventral tegmentum.