Nisin inhibits dental caries-associated microorganism in vitro
Nisin inhibits dental caries-associated microorganism in vitro
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DOI：
10.1016/j.peptides.2010.07.016
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发表时间：
2010-11-01
期刊：
影响因子：
3
通讯作者：
Ni, Longxing
中科院分区：
文献类型：
--
作者：
Tong, Zhongchun;Dong, Liping;Ni, Longxing
Nisin produced by Lactococcus lams is an antibiotic peptide to effectively antagonize a broad spectrum of Gram-positive bacteria and is widely used as a safe food antimicrobial agent In the present study we investigated whether nisin could be used as an effective antibiotic peptide against the nine common cariogenic microorganisms and its antimicrobial activity could be affected by the ingredients of saliva in oral cavity In the minimal inhibitory concentration (MIC) and minimal bactericide concentration (MBC) and spot-on-lawn assay nisin displayed different MIC MBC and antimicrobial activity against the nine tested strains There was statistical difference between the inhibitory zone diameters of nisin against the different tested bacteria (p < 0 05) but no statistical difference between the inhibitory zone diameters of nisin dissolved in PBS and saliva (p > 0 05) Furthermore morphology and membranes of Streptococcus sanguinis Streptococcus mutans Lactobacillus ferment, and Lactobacillus acidophilus with nisin treatment were observed and showed different degrees of variation by a Field Emission Scanning Electron Microscope (FE-SEM) Our findings suggested that nisin has considerable potential for prevention and treatment of dental canes (C) 2010 Elsevier Inc All rights reserved
