Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release
Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release
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DOI：
10.1097/wnr.0b013e3283036e5e
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发表时间：
2008-06-11
期刊：
影响因子：
1.7
通讯作者：
Blaha, Charles D.
中科院分区：
文献类型：
--
作者：
Lester, Deranda B.;Miller, Anthony D.;Blaha, Charles D.
本研究确定腹侧被盖区乙酰胆碱和谷氨酸受体在调节背侧被盖刺激引起的多巴胺在延髓核流出的作用。在乌拉坦麻醉的雄性小鼠中，用固定电位安培法在碳纤维微电极上测量多巴胺氧化电流的快速变化。腹侧被盖区的毒蕈碱型乙酰胆碱受体拮抗剂东莨菪碱，烟碱型乙酰胆碱受体拮抗剂美加明，或离子型谷氨酸受体拮抗剂犬尿氨酸的输液显着减少多巴胺流出引起的短暂电刺激的背侧被盖在延髓核。这些研究结果表明，乙酰胆碱和离子型谷氨酸受体影响快速多巴胺能活动，从而从腹侧被盖区多巴胺细胞前脑区的行为相关信息的通信。
This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in modulating laterodorsal tegmentum stimulation-evoked dopamine efflux in the nucleus accumbens. Rapid changes in dopamine oxidation current were measured at carbon fiber microelectrodes using fixed potential amperometry in urethane anesthetized male mice. Intraventral tegmental area infusions of the muscarinic acetylcholine receptor antagonist scopolamine, the nicotinic acetylcholine receptor antagonist mecamylamine, or the ionotropic glutamate receptor antagonist kynurenate significantly diminished dopamine efflux in the nucleus accumbens evoked by brief electrical stimulation of the laterodorsal tegmentum. These findings suggest that acetylcholine and ionotropic glutamate receptors influence rapid dopaminergic activity and thus the communication of behaviorally relevant information from ventral tegmental area dopamine cells to forebrain areas.