Size and shape effects in the biodistribution of intravascularly injected particles
Size and shape effects in the biodistribution of intravascularly injected particles
复制标题
DOI：
10.1016/j.jconrel.2009.10.014
复制
发表时间：
2010-02-15
影响因子：
10.8
通讯作者：
Ferrari, M.
中科院分区：
文献类型：
--
作者：
Decuzzi, P.;Godin, B.;Ferrari, M.
了解大小和形状如何影响血管内注射颗粒的生物分布对于合理设计给药系统以及从标准化和监管的角度来说都是至关重要的。在这项工作中，将直径为700 nm至3 μ m的未涂覆硅球珠和具有准半球形、圆柱形和盘状形状的未涂覆非球形硅基颗粒注射到荷瘤小鼠体内。通过单质硅（Si）分析测量了主要器官和肿瘤块内积聚的颗粒数量。对于球形微珠，随着直径d的增加，非res器官中积累的颗粒数量单调减少，这表明使用较小的颗粒可以提供更均匀的组织分布。然而，在大多数器官中，盘状颗粒比其他颗粒积聚更多，但在肝脏中，圆柱形颗粒沉积的程度更大。这些初步结果支持使用亚微米盘状颗粒作为血管内载体的概念，以最大化靶器官的积累，同时减少肝脏的隔离。(C) 2009 Elsevier B.V.版权所有
Understanding how size and shape can affect the biodistribution of intravascularly injected particles is of fundamental importance both for the rational design of delivery systems and from a standardization and regulatory view point. In this work, uncoated silica spherical beads, with a diameter ranging from 700 nm to 3 mu m, and uncoated non-spherical silicon-based particles, with quasi-hemispherical, cylindrical and discoidal shapes, have been injected into tumor bearing mice. The number of particles accumulating in the major organs and within the tumor mass has been measured through elemental silicon (Si) analysis. For the spherical beads, it has been found that the number of particles accumulating in the non-RES organs reduces monotonically as the diameter d increases, suggesting the use of smaller particles to provide a more uniform tissue distribution. However, discoidal particles have been observed to accumulate more than others in most of the organs but the liver, where cylindrical particles are deposited at a larger extent. These preliminary results support the notion of using sub-micrometer discoidal particles as intravascular carriers to maximize accumulation in the target organ whilst reducing sequestration by the liver. (C) 2009 Elsevier B.V. All rights reserved.