Intensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis: a High-Resolution Magnetic Resonance Imaging study (STAMINA-MRI Study)
Intensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis: a High-Resolution Magnetic Resonance Imaging study (STAMINA-MRI Study)
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DOI：
10.1136/jnnp-2019-320893
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发表时间：
2020-02-01
影响因子：
11
通讯作者：
Bang, Oh Young
中科院分区：
文献类型：
--
作者：
Chung, Jong-Won;Cha, Jihoon;Bang, Oh Young
目的 颅内动脉粥样硬化是全球缺血性脑卒中的主要病因。多项研究已表明他汀类药物治疗对冠状动脉和颈动脉斑块的作用，但关于他汀类药物治疗对颅内动脉粥样硬化斑块影响的证据较少。
方法 颅内动脉粥样硬化急性缺血性脑卒中患者强化他汀治疗 - 高分辨率磁共振成像（STAMINA - MRI）试验是一项单臂、前瞻性、观察性研究，监测初用他汀类药物的症状性颅内动脉粥样硬化所致急性缺血性脑卒中患者接受大剂量他汀治疗的影像学及临床结果。主要结局是通过高分辨率磁共振成像（HR - MRI）测量他汀治疗6个月（中位数：179天，四分位间距163 - 189天）前后血管重构和斑块特征的变化。
结果 本研究共纳入77例患者（平均年龄：62.6 ± 13.7岁，女性占61.0%）。初始评估和随访评估时的低密度脂蛋白胆固醇（LDL - C）水平（mg/dL）分别为125.81 ± 35.69和60.95 ± 19.28。总体而言，他汀治疗显著降低了斑块体积增强（mm³，32.07 ± 39.15对比17.06 ± 34.53，p = 0.013）、管壁面积指数（7.50 ± 4.28对比5.86 ± 4.05，p = 0.016）以及狭窄程度（%，76.47 ± 20.23对比64.05 ± 21.29，p...（此处原文似乎不完整）
Objective Intracranial atherosclerosis is a major cause of ischaemic stroke worldwide. A number of studies have shown the effects of statin treatment on coronary and carotid artery plaques, but there is little evidence on the effects of statin treatment on intracranial atherosclerotic plaques. Methods The Intensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis - High-Resolution Magnetic Resonance Imaging (STAMINA-MRI) Trial is a single-arm, prospective, observational study monitoring imaging and clinical outcomes of high-dose statin treatment among statin-naive patients with acute ischaemic stroke caused by symptomatic intracranial atherosclerosis. The primary outcome was the change in vascular remodelling and plaque characteristics before and after 6 months (median: 179 days, IQR 163-189 days) of statin treatment measured by high-resolution MRI (HR-MRI). Results A total of 77 patients (mean age: 62.6 +/- 13.7 years, 61.0% women) were included in this study. Low-density lipoprotein cholesterol (LDL-C) levels (mg/dL) at initial and follow-up assessments were 125.81 +/- 35.69 and 60.95 +/- 19.28, respectively. Overall, statin treatment significantly decreased enhancement of plaque volume (mm(3), 32.07 +/- 39.15 vs 17.06 +/- 34.53, p=0.013), the wall area index (7.50 +/- 4.28 vs 5.86 +/- 4.05, p=0.016) and stenosis degree (%, 76.47 +/- 20.23 vs 64.05 +/- 21.29, p