Narcotic antagonistic action of Cimetidine on the guinea‐pig ileum
Narcotic antagonistic action of Cimetidine on the guinea‐pig ileum
复制标题
西咪替丁对豚鼠回肠的麻醉拮抗作用
DOI：
10.1111/j.2042-7158.1978.tb13310.x
复制
发表时间：
1978
影响因子：
3.3
通讯作者：
Y. Kasuya
中科院分区：
文献类型：
--
作者：
I. Takayanagi;Y. Iwayama;Y. Kasuya
During investigations of actions of cimetidine, a histamine H,-receptor antagonist (Black, 1976) on isolated smooth muscles, we found that cimetidine antagonized the inhibitory action of morphine and leucine-enkeph a h , an endogenous opiate receptor ligand (Hughes, Smith &others, 1979, on the ileum from the guinea-pig. We therefore compared the mode of action of cimetidine on the ileum with that of a narcotic antagonist, naloxone. Male guinea-pigs, 250 to 350 g, were killed, the ileum leucine-enkephalin was much reduced by cimetidine M) and abolished by higher concentrations of cimetidine (3 X lo-' M) and naloxone (lo-"). Tetrodotoxin (5 x ~ O ' I M ) and strychnine (lo-* M) (Takagi & Takayanagi, 1966) also greatly reduced the twitch responses of the ileum. The inhibition by tetrodotoxin and strychnine was little influenced by naloxone ( 1 0 8 ~ ) and cimetidine (3 x M) and naloxone ( 3 x
