Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice
Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice
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DOI：
10.1128/iai.69.4.2762-2765.2001
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发表时间：
2001-04-01
影响因子：
3.1
通讯作者：
Kelly, CP
中科院分区：
文献类型：
--
作者：
Qamar, A;Aboudola, S;Kelly, CP
博氏酵母菌是一种非致病性酵母菌，可预防抗生素相关性腹泻和复发性艰难梭菌结肠炎。给鲍氏菌喂养的BALB/c小鼠灌胃艰难梭菌环状A可使其小肠总免疫球蛋白A水平升高1.8倍（P = 0.003），特异性肠道抗毒素A水平升高4.4倍（P < 0.001）。增强宿主肠道免疫反应可能是博拉氏菌介导的预防腹泻疾病的重要机制。
Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. difficile toroid A by gavage to S, boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P = 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels (P < 0.001). Enhancing host intestinal immune responses may be an important mechanism for S. boulardii-mediated protection against diarrheal illnesses.