An outbreak of coronavirus OC43 respiratory infection in Normandy, France
An outbreak of coronavirus OC43 respiratory infection in Normandy, France
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DOI：
10.1086/374222
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发表时间：
2003-04-15
影响因子：
11.8
通讯作者：
Freymuth, F
中科院分区：
文献类型：
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作者：
Vabret, A;Mourez, T;Freymuth, F
以原型株HCoV 229 E和HCoV OC 43为代表的两组人类冠状病毒（HCoV）大多被认为是引起普通感冒综合征的病毒。HCoV很难检测，流行病学数据也很罕见。从2000年10月至2001年4月，我们测试了1803呼吸道样本HCoV的逆转录聚合酶链反应。从2001年2月8日至3月27日，在501名患者中的30名（6%）样本中检测到HCoV OC 43。检出的其他病毒为呼吸道合胞病毒（6.1%）、副流感病毒3型（1%）、流感病毒A（7.8%）、流感病毒B（7.2%）、鼻病毒（6.4%）、肠道病毒（1%）和腺病毒（2%）。在所有年龄组的患者中均检测到HCoV OC 43感染。观察到以下临床症状：发热（59.8%的患者）、全身症状（30%）、消化问题（56.8%）、鼻炎（36.6%）、咽炎（30%）、喉炎（3.3%）、耳炎（13.3%）、支气管炎（16.6%）、细支气管炎（10%）和肺炎（6.6%）。这项研究表明，HCoV OC 43呼吸道感染的爆发是导致近三分之一通过冠状病毒感染主动监测确定的患者出现下呼吸道症状的原因。
The 2 groups of human coronaviruses (HCoVs) represented by the prototype strains HCoV 229E and HCoV OC43 are mostly known as viruses responsible for common cold syndrome. HCoVs are difficult to detect, and epidemiological data are rare. From October 2000 through April 2001, we tested 1803 respiratory samples for HCoV by reverse-transcriptase polymerase chain reaction. From 8 February through 27 March 2001, HCoV OC43 was detected in samples obtained from 30 (6%) of 501 patients. The other viruses detected were respiratory syncytial virus (6.1%), parainfluenza virus 3 (1%), influenza virus A (7.8%), influenza virus B (7.2%), rhinovirus (6.4%), enterovirus (1%), and adenovirus (2%). Infection with HCoV OC43 was detected in patients of all age groups. The following clinical symptoms were noted: fever (in 59.8% of patients), general symptoms (in 30%), digestive problems (in 56.8%), rhinitis (in 36.6%), pharyngitis (in 30%), laryngitis (in 3.3%), otitis (in 13.3%), bronchitis (in 16.6%), bronchiolitis (in 10%), and pneumonia (in 6.6%). This study shows that an outbreak of HCoV OC43 respiratory infection was responsible for the lower respiratory tract symptoms observed in nearly one-third of patients identified by active surveillance for coronavirus infection.