Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring
Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring
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产前高雄激素环境诱发大鼠后代的自闭症样行为
DOI：
10.1016/j.physbeh.2014.09.014
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发表时间：
2015-01
影响因子：
2.9
通讯作者：
Han, Ji-Sheng
中科院分区：
文献类型：
--
作者：
Qian, Yi;Han, Song-Ping;Zhang, Rong;Han, Ji-Sheng
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by persistent impairment in social communication and social interaction. Recent studies revealed that environmental factors, especially the intrauterine developmental environment, played important roles in the development of ASD. It is hypothesized that maternal hyperandrogenism during pregnancy may increase the susceptibility of the fetus to ASD. In the present study, pregnant rats were treated with a low dose of letrozole (1 μg/kg/day) in an attempt to produce a hyperandrogenic intrauterine environment for the developing fetus. Results showed that rat pups prenatally exposed to hyperandrogenic intrauterine environment emitted less number of ultrasonic vocalizations when isolated from their dams and littermates. Additionally, the female rats in the treatment group spent less time in social interaction in adolescence and exhibited impaired heterosexual interaction in adult. Moreover, the duration of social interaction and heterosexual interaction of the female offspring were negatively correlated with maternal serum testosterone levels during pregnancy. These results suggest that prenatal exposure to hyperandrogenic intrauterine environment could induce autistic-like behavior in female rats and maternal hyperandrogenism during pregnancy should be considered as a potential risk factor for the etiology of ASD.
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影响因子：
3.7
作者：
Sarachana T;Xu M;Wu RC;Hu VW
通讯作者：
Hu VW
DOI：
10.1056/nejmoa1307491
发表时间：
2014-03-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Stoner R;Chow ML;Boyle MP;Sunkin SM;Mouton PR;Roy S;Wynshaw-Boris A;Colamarino SA;Lein ES;Courchesne E
通讯作者：
Courchesne E
影响因子：
2.9
作者：
Shepard, Kathryn N.;Michopoulos, Vasiliki;Toufexis, Donna J.;Wilson, Mark E.
通讯作者：
Wilson, Mark E.
影响因子：
--
作者：
通讯作者：
--
DOI：
10.14293/s2199-1006.1.sor-med.clem1hj.v1
发表时间：
2017-10
期刊：
--
影响因子：
--
作者：
ScienceOpen Admin
通讯作者：
ScienceOpen Admin