Markers of inflammation and oxidative stress in exacerbated chronic obstructive pulmonary disease patients
Markers of inflammation and oxidative stress in exacerbated chronic obstructive pulmonary disease patients
复制标题
DOI：
10.1016/j.rmed.2004.04.017
复制
发表时间：
2005-01-01
影响因子：
4.3
通讯作者：
Haas, FJLM
中科院分区：
文献类型：
--
作者：
Gerritsen, WBM;Asin, J;Haas, FJLM
慢性阻塞性肺疾病的特点是炎症过程对小气道的损害，以及氧化剂和抗氧化剂之间的失衡。几种细胞因子和细胞黏附分子增强了以中性粒细胞为主的炎症，与COPD有关。圣安东尼奥医院收治的14例中重度COPD患者入院时24小时内接受强的松龙50 mg静脉注射治疗，第3天减至25 mg，第7天逐渐停用强的松龙。分别于第1、3、7天测定呼出空气中的过氧化氢、IL-8和血清中的可溶性细胞黏附分子sICAM和sE-选择素。此外，我们还及时检查了研究组在治疗过程中的变化。入院时各项指标均较对照组升高。治疗期间，呼气冷凝液中的过氧化氢浓度显着下降(P
COPD is characterised by damage to small airways due to an inflammatory process as well as an imbalance between oxidants and antioxidants. Several cytokines and cell adhesion molecules enhancing a mainly neutrophilic inflammation have been associated with COPD. The aim of the study was to investigate whether inflammation or oxidative markers gave an indication of the course of COPD during an exacerbation.Fourteen patients with moderate to severe COPD admitted to the St.Antonius Hospital because of an exacerbation have been monitored during treatment with prednisolone 50 mg intravenously during 24 h at admission, reduced to 25 mg at day 3 and tapered off with oral prednisolone at day 7. On three separate occasions, day 1, 3 and 7, H2O2 in exhaled air, IL-8 and the soluble cell adhesion molecule sICAM and sE-selectin in serum were measured.We compared the patients at day 1 with healthy controls (in both non-smokers and smokers). Furthermore, we examined the changes from the study group in time during therapy. At admission all the markers were raised in comparison with the control groups. During treatment H2O2 concentrations in breath condensate declined significantly (P