A PROSPECTIVE-STUDY OF DENGUE INFECTIONS IN BANGKOK
A PROSPECTIVE-STUDY OF DENGUE INFECTIONS IN BANGKOK
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DOI：
10.4269/ajtmh.1988.38.172
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发表时间：
1988-01-01
影响因子：
3.3
通讯作者：
SCOTT, RM
中科院分区：
文献类型：
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作者：
BURKE, DS;NISALAK, A;SCOTT, RM
对曼谷一所学校4至16岁学生的登革热感染进行了前瞻性研究。1980年6月（登革热季节前）和1981年1月（登革热季节后）采集了1757名学生的血液样本，并用血凝抑制法检测登革热抗体。教室每天都被监控是否有缺勤。在研究期间，50%的儿童有至少一种登革热病毒抗体，并且可能对其免疫，这些儿童要么无症状，要么症状轻微（仅1天缺席）。大多数（7/13,53%）有症状的登革热感染（不伴有发热）。2 d)的病例临床诊断为登革出血热，需要住院治疗，56例继发感染中有7例需要住院治疗（P = 0.012）。通过常规血清学技术检测到的既往登革热免疫是显著的（优势比）。6.5)登革出血热发生的危险因素。
Dengue infections were prospectively studied among 4- to 16-year-old students at a Bangkok school. Blood samples were obtained from 1,757 students in June 1980, before the dengue season, and in January 1981, after the season, and tested for dengue antibodies by the hemagglutination inhibition method. Classrooms were monitored daily for school absences. Fifty percent of the children had antibodies to and were presumably immune to, at least 1 dengue viruses during the study period were either asymptomatic or minimally symptomatic (absent only 1 dy). Most (7/13, 53%) of the symptomatic dengue infections (absent with fever for .gtoreq. 2 days) were clinically recognized as cases of dengue hemorrhagic fever which required hospitalization, whereas 7 of 56 secondary infections did (P = 0.012). Preexist dengue immunity, as detected by conventional serologic techniques, was a significant (odds ratio .gtoreq. 6.5) risk factor for development of dengue hemorrhagic fever.