Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making
Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making
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DOI：
10.1007/s40615-018-0505-y
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发表时间：
2019-02-01
影响因子：
3.9
通讯作者：
Bonham, Vence L.
中科院分区：
文献类型：
--
作者：
Sellers, Sherrill L.;Cunningham, Brooke A.;Bonham, Vence L.
在美国，种族与健康和幸福有着持久的联系。它通常被用作祖先和遗传变异的代表，尽管自我认定的种族并不能确定个体患者的疾病遗传风险。医生如何调和这些看似矛盾的事实，因为他们使临床decisions. Objectiveinvestigate医生的遗传知识和信念的种族与他们使用的种族在临床decision-making设计横断面调查的全国样本的临床活跃的普通internistsResultsSeventhighty-een医生完成了调查。回归模型表明，遗传知识与种族的使用没有显着相关。然而，医生谁同意种族作为一种生物现象的概念，那些谁同意种族具有临床重要性的更有可能报告使用种族在他们的decision-making.ConclusionsGenomic和精准医学具有相当大的希望缩小差距在美国种族群体之间的健康。为了实现这一承诺，我们的研究结果表明，未来与种族，基因组学和健康相关的研究和教育工作必须超越教育医疗保健提供者关于常见遗传条件的知识，深入研究关于种族和遗传学的假设。
BackgroundRace in the USA has an enduring connection to health and well-being. It is often used as a proxy for ancestry and genetic variation, although self-identified race does not establish genetic risk of disease for an individual patient. How physicians reconcile these seemingly paradoxical facts as they make clinical decisions is unknown.ObjectiveTo examine physicians' genetic knowledge and beliefs about race with their use of race in clinical decision-makingDesignCross-sectional survey of a national sample of clinically active general internistsResultsSeven hundred eighty-seven physicians completed the survey. Regression models indicate that genetic knowledge was not significantly associated with use of race. However, physicians who agreed with notions of race as a biological phenomenon and those who agreed that race has clinical importance were more likely to report using race in their decision-making.ConclusionsGenomic and precision medicine holds considerable promise for narrowing the gap in health among racial groups in the USA. For this promise to be realized, our findings suggest that future research and education efforts related to race, genomics, and health must go beyond educating health care providers about common genetic conditions to delving into assumptions about race and genetics.