Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.
Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.
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DOI：
10.1364/ol.42.000017
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发表时间：
2017-01-01
期刊：
影响因子：
3.6
通讯作者：
Farsiu S
中科院分区：
文献类型：
--
作者：
Polans J;Cunefare D;Cole E;Keller B;Mettu PS;Cousins SW;Allingham MJ;Izatt JA;Farsiu S
光学相干断层扫描血管造影术（OCTA）是一种很有前途的技术，用于无创可视化血管网络在人眼。我们首次推出了一种能够采集宽视场（>70°）OCT血管造影片而无马赛克的系统。此外，我们报告使用波前无传感器自适应光学（WSAO）增强外周微血管的可视化。我们采用了快速WSAO算法，该算法通过以OCT B扫描而不是体积的速度迭代镜形状，在<2秒内实现波前校正。此外，我们对比了在周围采集的~7°视野OCTA血管造影片（有和无WSAO校正）。平均而言，WSAO使健康眼的微血管清晰度提高了65%，使患病眼的微血管清晰度提高了38%。初步观察表明，7°图像的位置可以直接从宽视野血管造影片中识别。一项针对正常受试者和糖尿病视网膜病变患者的初步研究显示了在可视化外周血管病变时使用WSAO进行OCTA的影响。
Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view (>70°) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in <2 seconds by iterating the mirror shape at the speed of OCT B-scans rather than volumes. Also, we contrasted ~7° field-of-view OCTA angiograms acquired in the periphery with and without WSAO correction. On average, WSAO improved the sharpness of microvasculature by 65% in healthy and 38% in diseased eyes. Preliminary observations demonstrated that the location of 7° images could be identified directly from the wide field-of-view angiogram. A pilot study on a normal subject and patients with diabetic retinopathy showed the impact of utilizing WSAO for OCTA when visualizing peripheral vasculature pathologies.