Differences in cancer stage, treatment and in-hospital mortality between patients with and without schizophrenia: retrospective matched-pair cohort study
Differences in cancer stage, treatment and in-hospital mortality between patients with and without schizophrenia: retrospective matched-pair cohort study
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DOI：
10.1192/bjp.bp.114.156265
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发表时间：
2016-03-01
影响因子：
10.5
通讯作者：
Kawakami, Norito
中科院分区：
文献类型：
--
作者：
Ishikawa, Hanako;Yasunaga, Hideo;Kawakami, Norito
背景癌症精神分裂症患者的医疗保健获取和结果仍不清楚。目的调查患有癌症的精神分裂症患者早期诊断和治疗的可能性及其预后。方法利用日本国家住院患者数据库确定了胃肠道癌症患者的回顾性配对队列。建立多变量序数/二元逻辑回归模型，比较精神分裂症患者 (n = 2495) 和无精神疾病患者 (n = 9980) 入院时的癌症分期、侵入性治疗和 30 天住院死亡率。 结果 病例组 IV 期癌症比例较高（33.9% vs. 18.1%），侵入性治疗比例较低 （56.5% vs. 70.2%，比值比 (OR) = 0.77，95% CI 0.69-0.85）和更高的院内死亡率（4.2% vs. 1.8%，OR = 1.35，95% CI 1.04-1.75）。 结论 患有胃肠癌的精神分裂症患者患有晚期癌症，可能性较低侵入性治疗及更高 院内死亡率高于没有精神疾病的患者。
BackgroundHealthcare access and outcomes in cancer patients with schizophrenia remain unclear.AimsTo investigate the likelihood of early diagnosis and treatment in patients with schizophrenia who have cancer and their prognosis.MethodA retrospective matched-pair cohort of gastrointestinal cancer patients was identified using a national in-patient database in Japan. Multivariable ordinal/binary logistic regressions was modelled to compare cancer stage at admission, invasive treatments and 30-day in-hospital mortality between patients with schizophrenia (n = 2495) and those without psychiatric disorders (n = 9980).ResultsThe case group had a higher proportion of stage IV cancer (33.9% v. 18.1%), a lower proportion of invasive treatment (56.5% v. 70.2%, odds ratio (OR) = 0.77, 95% CI 0.69-0.85) and higher in-hospital mortality (4.2% v. 1.8%, OR = 1.35, 95% CI 1.04-1.75).ConclusionsPatients with schizophrenia who had gastrointestinal cancer had more advanced cancer, a lower likelihood of invasive treatment and higher in-hospital mortality than those without psychiatric disorders.