Adrenergic regulation of ileocecal sphincter function in the cat
Adrenergic regulation of ileocecal sphincter function in the cat
复制标题
猫回盲部括约肌功能的肾上腺素调节
DOI：
10.1016/0016-5085(80)90186-9
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发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
Sidney R. Cohen
中科院分区：
文献类型：
--
作者：
M. Rubin;J. Fournet;W. Snape;Sidney R. Cohen
回盲部括约肌（ICS）的神经控制知之甚少。本研究的目的是评价：（a）ICS和血压对α-和β-肾上腺素能激动剂和拮抗剂的反应;和（B）ICS对直接刺激或切断内脏大神经的反应。在麻醉猫中，ICS的长度为1.36 ± 0.05 cm（平均值± SEM），基础压维持在23.5 ± 1.5 mm Hg。苯肾上腺素使ICS压力呈剂量依赖性增加，最大反应为16.0 ± 2.0 mm Hg。异丙肾上腺素使ICS压力最大降低51.2 ± 3.4%。酚妥拉明使ICS压力降低61.3 ± 2.8%，但普萘洛尔无影响。切断内脏大神经对基础ICS压力没有影响。电刺激切断的神经外周端，在10 V，10 Hz下产生括约肌压力的最大增加16.0 ± 1.5 mm Hg。这种反应被酚妥拉明拮抗，但不被普萘洛尔或阿托品。刺激内脏神经中央端对ICS压力没有影响。肾上腺素能药物和内脏刺激不影响回肠或结肠运动。这些研究表明：（a）ICS是高压区，其显示对外周内脏神经刺激和α-肾上腺素能激动剂的兴奋性反应;（B）β-肾上腺素能刺激抑制ICS压力，但在对内脏神经刺激的反应中不起明显作用;和（c）ICS的反应不同于邻近的回肠或结肠。
The neural control of the ileocecal sphincter (ICS) is poorly understood. The purpose of this study is to evaluate: (a) ICS and blood pressure responses to alpha- and beta-adrenergic agonists and antagonists; and (b) the ICS response to direct stimulation or section of the greater splanchnic nerves. In the anesthetized cat, the ICS is 1.36 ± 0.05 cm (mean ± SEM) in length and maintains a basal pressure of 23.5 ± 1.5 mm Hg. Phenylephrine gave a dose-dependent increase in ICS pressure with a maximal response of 16.0 ± 2.0 mm Hg. Isoproterenol gave a maximum reduction in ICS pressure of 51.2 ± 3.4%. Phentolamine decreased ICS pressure by 61.3 ± 2.8%, but propranolol had no effect. Section of the greater splanchnic nerve had no effect on basal ICS pressure. Electrical stimulation of the cut peripheral end of the nerve produced a maximal increase in sphincter pressure of 16.0 ± 1.5 mm Hg at 10 V, 10 Hz. This response was antagonized by phentolamine, but not by propranolol or atropine. Stimulation of the central end of the splanchnic nerve had no effect on ICS pressure. Adrenergic drugs and splanchnic stimulation did not affect ileal or colonic motility. These studies indicate that: (a) the ICS is a high pressure zone that shows an excitatory response to peripheral splanchnic nerve stimulation and alpha-adrenergic agonists; (b) beta-adrenergic stimulation inhibits ICS pressure, but plays no apparent role in the response to splanchnic stimulation; and (c) the ICS responds differently than the adjacent ileum or colon.