An intrinsically disordered proteins community for ELIXIR.
An intrinsically disordered proteins community for ELIXIR.
复制标题
DOI：
10.12688/f1000research.20136.1
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Tosatto, Silvio C E
中科院分区：
文献类型：
--
作者：
Davey, Norman E;Babu, M Madan;Tosatto, Silvio C E
本质无序蛋白（IDP）和本质无序区域（IDR）现在被认为是细胞调节的主要决定因素。本白皮书提出了 ELIXIR 框架内 IDP 研究领域未来电子基础设施发展的路线图。这些开发的目标是推动高质量工具和资源的创建，以支持国内流离失所者的识别、分析和功能表征。该路线图是在帕多瓦大学举办的题为“ELIXIR 本质上无序的蛋白质用户社区提案”研讨会的结果。研讨会并与更广泛的国内流离失所者社区成员进一步协商，确定了路线图的关键优先领域，包括制定数据注释、存储和传播标准；将 IDP 数据集成到 ELIXIR 核心数据资源中；以及为 IDP 相关软件创建基准测试标准。在这里，我们讨论这些优先领域、如何与 ELIXIR 平台合作实施它们，以及它们与现有 ELIXIR 社区和国际财团的联系。本文为 ELIXIR 中的 IDP 社区提供了初步蓝图，并呼吁确定并吸引新的利益相关者。
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.