MONO-AMINE INNERVATION OF RAT CEREBRAL-CORTEX - SYNAPTIC AND NON-SYNAPTIC AXON TERMINALS
MONO-AMINE INNERVATION OF RAT CEREBRAL-CORTEX - SYNAPTIC AND NON-SYNAPTIC AXON TERMINALS
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DOI：
10.1016/0306-4522(78)90115-x
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发表时间：
1978-01-01
期刊：
影响因子：
3.3
通讯作者：
DESCARRIES, L
中科院分区：
文献类型：
--
作者：
BEAUDET, A;DESCARRIES, L
最近在哺乳动物大脑单胺能系统上进行的实验获得的大量证据表明，神经细胞之间的分子通信可能采取不同于传统突触传递的各种形式。在中枢神经系统的某些部位，很高比例的单胺类轴突终末缺乏电子显微镜下突触所特有的膜性对位和特化。这一发现表明，从这种非突触神经末梢释放的生物胺可能到达远程受体，这是一种介于经典突触信使的精确寻址和神经内分泌广播之间的操作模式。本论文的目的是回顾引起这一假说的放射自显影数据的主要内容，并简要讨论它们的一些细胞学和功能意义。
Substantial evidence recently obtained from experiments carried out on the monoaminergic systems of the mammalian brain indicates that molecular communication between nerve cells may take various forms differing from the traditional views on synaptic transmission. In certain parts of the CNS a high proportion of monoamine axon terminals lacks the membranous apposition and specializations which characterize synapses in electron micrographs. This finding led to the suggestion that the biogenic amines released from such nonsynaptic nerve endings might reach remote receptors, a mode of operation intermediate between the prviate addressing of classical synaptic messengers and the broadcasting of neuroendocrine secretion. The purpose of the present paper is to recall the main body of radioautographic data that gave rise to this hypothesis and briefly discuss some of their cytological and functional implications.